The principal features and mechanisms of dopamine modulation in the prefrontal cortex

JK Seamans, CR Yang - Progress in neurobiology, 2004 - Elsevier
Mesocotical dopamine (DA) inputs to the prefrontal cortex (PFC) play a crtical role in normal
cognitive process and neuropsychiatic pathologies. This DA input regulates aspects of …

Dopamine receptor signaling

KA Neve, JK Seamans… - Journal of receptors and …, 2004 - Taylor & Francis
The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has shared
signaling properties that contribute to the definition of the receptor class, although some …

Neurocomputational models of working memory

D Durstewitz, JK Seamans, TJ Sejnowski - Nature neuroscience, 2000 - nature.com
During working memory tasks, the firing rates of single neurons recorded in behaving
monkeys remain elevated without external cues. Modeling studies have explored different …

Selective roles for hippocampal, prefrontal cortical, and ventral striatal circuits in radial-arm maze tasks with or without a delay

SB Floresco, JK Seamans, AG Phillips - Journal of Neuroscience, 1997 - Soc Neuroscience
The hippocampus, the prefrontal cortex, and the ventral striatum form interconnected neural
circuits that may underlie aspects of spatial cognition and memory. In the present series of …

[HTML][HTML] Dopamine-mediated stabilization of delay-period activity in a network model of prefrontal cortex

D Durstewitz, JK Seamans… - Journal of …, 2000 - journals.physiology.org
The prefrontal cortex (PFC) is critically involved in working memory, which underlies memory-guided,
goal-directed behavior. During working-memory tasks, PFC neurons exhibit …

Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons

JK Seamans, D Durstewitz… - Proceedings of the …, 2001 - National Acad Sciences
Dopamine acts mainly through the D1/D5 receptor in the prefrontal cortex (PFC) to
modulate neural activity and behaviors associated with working memory. To understand the …

D1 receptor modulation of hippocampal–prefrontal cortical circuits integrating spatial memory with executive functions in the rat

JK Seamans, SB Floresco, AG Phillips - Journal of neuroscience, 1998 - Soc Neuroscience
Dopamine (DA) within the prefrontal cortex (PFC) plays an important role in modulating the
short-term retention of information during working memory tasks. In contrast, little is known …

Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons

JK Seamans, N Gorelova, D Durstewitz… - Journal of …, 2001 - Soc Neuroscience
Dopamine regulates the activity of neural networks in the prefrontal cortex that process
working memory information, but its precise biophysical actions are poorly understood. The …

The dual-state theory of prefrontal cortex dopamine function with relevance to catechol-o-methyltransferase genotypes and schizophrenia

D Durstewitz, JK Seamans - Biological psychiatry, 2008 - Elsevier
There is now general consensus that at least some of the cognitive deficits in schizophrenia
are related to dysfunctions in the prefrontal cortex (PFC) dopamine (DA) system. At the …

Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking

…, RI Melendez, PW Kalivas, JK Seamans - Journal of …, 2005 - Soc Neuroscience
Withdrawal from chronic cocaine reduces extracellular glutamate levels in the nucleus
accumbens by decreasing cystine/glutamate exchange (xc-). Activating xc- with N-acetylcysteine …