Executive functions supported by prefrontal cortical (PFC) systems provide essential control
and planning mechanisms to guide goal-directed behavior. As such, age-related alterations …

The identification of neurogenesis in the dentate gyrus of adult mammals has sparked much
interest in a functional role for these new neurons in hippocampal‐dependent cognition. …

Alterations in inhibitory interneurons contribute to cognitive deficits associated with several
psychiatric and neurological diseases. Phasic and tonic inhibition imparted by γ-aminobutyric …

We developed a behavioral task in rats to assess the influence of risk of punishment on
decision making. Male Long–Evans rats were given choices between pressing a lever to obtain …

Many psychiatric disorders are characterized by abnormal risky decision-making and
dysregulated dopamine receptor expression. The current study was designed to determine how …

Many debilitating psychiatric conditions, including drug addiction, are characterized by poor
decision making and maladaptive risk-taking. Recent research has begun to probe this …

With the population of older adults expected to grow rapidly over the next two decades, it
has become increasingly important to advance research efforts to elucidate the mechanisms …

Working memory functions supported by the prefrontal cortex decline in normal aging.
Disruption of corticolimbic GABAergic inhibitory circuits can impair working memory in young …

Several neuropsychiatric disorders are associated with abnormal decision-making involving
risk of punishment, but the neural basis of this association remains poorly understood. …

Animal models have contributed significantly to our understanding of the underlying biological
mechanisms of Alzheimer's disease (AD). As a result, over 300 interventions have been …