Dopamine cell firing can encode errors in reward prediction, providing a learning signal to
guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating …

The dopamine projection from ventral tegmental area (VTA) to nucleus accumbens (NAc) is
critical for motivation to work for rewards and reward-driven learning. How dopamine …

Beta oscillations in cortical-basal ganglia (BG) circuits have been implicated in normal
movement suppression and motor impairment in Parkinson's disease. To dissect the functional …

Fast-spiking interneurons (FSIs) can exert powerful control over striatal output, and deficits
in this cell population have been observed in human patients with Tourette syndrome and …

Objective. Multimodal measurements at the neuronal level allow for detailed insight into local
circuit function. However, most behavioral studies focus on one or two modalities and are …

Psychomotor stimulants and typical antipsychotic drugs have powerful but opposite effects on
mood and behavior, largely through alterations in striatal dopamine signaling. Exactly how …

Genetically modified mice have become standard tools in neuroscience research. Our
understanding of the basal ganglia in particular has been greatly assisted by BAC mutants with …

Neural implants with large numbers of electrodes have become an important tool for examining
brain functions. However, these devices typically displace a large intracranial volume …

… Ali Mohebi & Jeffrey R. Pettibone & Arif A. Hamid & Jenny-Marie T. Wong & Leah T. …
Laurens Winkelmeier & Carla Filosa & Renée Hartig & Max Scheller & Markus Sack & Jonathan …

Rats have the ability to learn and perform sophisticated behavioral tasks, making them very
useful for investigating neural circuit functions. In contrast to the extensive mouse genetic …