IKK-β links inflammation to obesity-induced insulin resistance
…, AL Hevener, FR Greten, S Maeda, ZW Li, JM Long… - Nature medicine, 2005 - nature.com
Inflammation may underlie the metabolic disorders of insulin resistance and type 2 diabetes.
IκB kinase β (IKK-β, encoded by Ikbkb) is a central coordinator of inflammatory responses …
IκB kinase β (IKK-β, encoded by Ikbkb) is a central coordinator of inflammatory responses …
SIRT1 is essential for normal cognitive function and synaptic plasticity
Conservation of normal cognitive functions relies on the proper performance of the nervous
system at the cellular and molecular level. The mammalian nicotinamide-adenine …
system at the cellular and molecular level. The mammalian nicotinamide-adenine …
Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats
The adult brain contains neural stem cells that are capable of proliferating, differentiating into
neurons or glia, and then either surviving or dying. This process of neural-cell production (…
neurons or glia, and then either surviving or dying. This process of neural-cell production (…
[HTML][HTML] Discovery of a proneurogenic, neuroprotective chemical
AA Pieper, S Xie, E Capota, SJ Estill, J Zhong, JM Long… - Cell, 2010 - cell.com
An in vivo screen was performed in search of chemicals capable of enhancing neuron
formation in the hippocampus of adult mice. Eight of 1000 small molecules tested enhanced …
formation in the hippocampus of adult mice. Eight of 1000 small molecules tested enhanced …
Age and gender effects on microglia and astrocyte numbers in brains of mice
PR Mouton, JM Long, DL Lei, V Howard, M Jucker… - Brain research, 2002 - Elsevier
The morphological changes that occur during normal brain aging are not well understood.
This study used modern stereology to assess the effects of age and gender on total numbers …
This study used modern stereology to assess the effects of age and gender on total numbers …
Doublecortin is required in mice for lamination of the hippocampus but not the neocortex
JC Corbo, TA Deuel, JM Long, P LaPorte… - Journal of …, 2002 - Soc Neuroscience
Doublecortin (DCX) is a microtubule-associated protein that is required for normal neocortical
and hippocampal development in humans. Mutations in the X-linked human DCX gene …
and hippocampal development in humans. Mutations in the X-linked human DCX gene …
[HTML][HTML] Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice
…, JC Monte, T Rieg, DM Truong, JM Long… - Journal of Biological …, 2006 - ASBMB
The "classical" organic anion secretory pathway of the renal proximal tubule is critical for the
renal excretion of the prototypic organic anion, para-aminohippurate, as well as of a large …
renal excretion of the prototypic organic anion, para-aminohippurate, as well as of a large …
N-Glycolylneuraminic Acid Deficiency in Mice: Implications for Human Biology and Evolution
…, H Takematsu, JM Long… - … and cellular biology, 2007 - Taylor & Francis
Humans and chimpanzees share >99% identity in most proteins. One rare difference is a
human-specific inactivating deletion in the CMAH gene, which determines biosynthesis of the …
human-specific inactivating deletion in the CMAH gene, which determines biosynthesis of the …
Hippocampal neuron and synaptophysin-positive bouton number in aging C57BL/6 mice
ME Calhoun, D Kurth, AL Phinney, JM Long… - Neurobiology of …, 1998 - Elsevier
A loss of hippocampal neurons and synapses had been considered a hallmark of normal
aging and, furthermore, to be a substrate of age-related learning and memory deficits. Recent …
aging and, furthermore, to be a substrate of age-related learning and memory deficits. Recent …
Prefrontal cortex and working memory for spatial response, spatial location, and visual object information in the rat
RP Kesner, ME Hunt, JM Williams, JM Long - Cerebral Cortex, 1996 - academic.oup.com
In the first experiment, rats were trained on a working memory task for a spatial response (right-left
turn) information using a delayed matching-to-sample procedure. Following lesions of …
turn) information using a delayed matching-to-sample procedure. Following lesions of …