IKK-β links inflammation to obesity-induced insulin resistance

…, AL Hevener, FR Greten, S Maeda, ZW Li, JM Long… - Nature medicine, 2005 - nature.com
Inflammation may underlie the metabolic disorders of insulin resistance and type 2 diabetes.
IκB kinase β (IKK-β, encoded by Ikbkb) is a central coordinator of inflammatory responses …

SIRT1 is essential for normal cognitive function and synaptic plasticity

…, JM Long, JS Allard, K Lewis, M Miller… - Journal of …, 2010 - Soc Neuroscience
Conservation of normal cognitive functions relies on the proper performance of the nervous
system at the cellular and molecular level. The mammalian nicotinamide-adenine …

Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats

J Lee, W Duan, JM Long, DK Ingram… - Journal of Molecular …, 2000 - Springer
The adult brain contains neural stem cells that are capable of proliferating, differentiating into
neurons or glia, and then either surviving or dying. This process of neural-cell production (…

[HTML][HTML] Discovery of a proneurogenic, neuroprotective chemical

AA Pieper, S Xie, E Capota, SJ Estill, J Zhong, JM Long… - Cell, 2010 - cell.com
An in vivo screen was performed in search of chemicals capable of enhancing neuron
formation in the hippocampus of adult mice. Eight of 1000 small molecules tested enhanced …

Age and gender effects on microglia and astrocyte numbers in brains of mice

PR Mouton, JM Long, DL Lei, V Howard, M Jucker… - Brain research, 2002 - Elsevier
The morphological changes that occur during normal brain aging are not well understood.
This study used modern stereology to assess the effects of age and gender on total numbers …

Doublecortin is required in mice for lamination of the hippocampus but not the neocortex

JC Corbo, TA Deuel, JM Long, P LaPorte… - Journal of …, 2002 - Soc Neuroscience
Doublecortin (DCX) is a microtubule-associated protein that is required for normal neocortical
and hippocampal development in humans. Mutations in the X-linked human DCX gene …

[HTML][HTML] Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice

…, JC Monte, T Rieg, DM Truong, JM Long… - Journal of Biological …, 2006 - ASBMB
The "classical" organic anion secretory pathway of the renal proximal tubule is critical for the
renal excretion of the prototypic organic anion, para-aminohippurate, as well as of a large …

N-Glycolylneuraminic Acid Deficiency in Mice: Implications for Human Biology and Evolution

…, H Takematsu, JM Long… - … and cellular biology, 2007 - Taylor & Francis
Humans and chimpanzees share >99% identity in most proteins. One rare difference is a
human-specific inactivating deletion in the CMAH gene, which determines biosynthesis of the …

Hippocampal neuron and synaptophysin-positive bouton number in aging C57BL/6 mice

ME Calhoun, D Kurth, AL Phinney, JM Long… - Neurobiology of …, 1998 - Elsevier
A loss of hippocampal neurons and synapses had been considered a hallmark of normal
aging and, furthermore, to be a substrate of age-related learning and memory deficits. Recent …

Prefrontal cortex and working memory for spatial response, spatial location, and visual object information in the rat

RP Kesner, ME Hunt, JM Williams, JM Long - Cerebral Cortex, 1996 - academic.oup.com
In the first experiment, rats were trained on a working memory task for a spatial response (right-left
turn) information using a delayed matching-to-sample procedure. Following lesions of …