User profiles for Jeff Milbrandt
Jeffrey MilbrandtJames S McDonnell Professor of Genetics, Washington University Verified email at wustl.edu Cited by 49967 |
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
T Araki, Y Sasaki, J Milbrandt - Science, 2004 - science.org
Axonal degeneration is an active program of self-destruction that is observed in many
physiological and pathological settings. In Wallerian degeneration slow (wld s ) mice, Wallerian …
physiological and pathological settings. In Wallerian degeneration slow (wld s ) mice, Wallerian …
Neurturin, a relative of glial-cell-line-derived neurotrophic factor
…, JP Golden, DJ Creedon, EM Johnson Jr, J Milbrandt - Nature, 1996 - nature.com
THE normal development of the vertebrate nervous system entails the death of 30–70% of the
neurons originally generated in most neuronal populations 1 . This naturally occurring cell …
neurons originally generated in most neuronal populations 1 . This naturally occurring cell …
Expression profiling reveals hepsin overexpression in prostate cancer
Prostate cancer is the most commonly diagnosed noncutaneous cancer in men. Despite this
fact, many of the genetic changes that coincide with prostate cancer progression remain …
fact, many of the genetic changes that coincide with prostate cancer progression remain …
[HTML][HTML] FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression: implications for PTEN mutation in prostate cancer
V Modur, R Nagarajan, BM Evers, J Milbrandt - Journal of Biological …, 2002 - ASBMB
Mutations in PTEN occur in 60–80% of prostate cancers and lead to a constitutive activation
of the phosphatidylinositol 3-kinase pathway and a resultant loss of activity of the FOXO …
of the phosphatidylinositol 3-kinase pathway and a resultant loss of activity of the FOXO …
NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli
…, DB Zimonjic, NC Popescu, J Milbrandt - … and cellular biology, 1996 - Am Soc Microbiol
Previous work had identified a corepressor, NAB1, which represses transcriptional activation
mediated by NGFI-A (also known as Egr-1, zif268, and Krox24) and Krox20. These zinc …
mediated by NGFI-A (also known as Egr-1, zif268, and Krox24) and Krox20. These zinc …
Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons
…, L Simmons, E Johnson, J Milbrandt… - Journal of …, 1998 - Soc Neuroscience
Glial cell line-derived neurotrophic factor (GDNF) exhibits potent effects on survival and
function of midbrain dopaminergic (DA) neurons in a variety of models. Although other growth …
function of midbrain dopaminergic (DA) neurons in a variety of models. Although other growth …
[PDF][PDF] Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons
…, A Bruce, RO Heuckeroth, EM Johnson, J Milbrandt - Neuron, 2002 - cell.com
Artemin (ARTN) is a member of the GDNF family of ligands and signals through the Ret/GFRα3
receptor complex. Characterization of ARTN- and GFRα3-deficient mice revealed similar …
receptor complex. Characterization of ARTN- and GFRα3-deficient mice revealed similar …
Conditional loss of Nkx3. 1 in adult mice induces prostatic intraepithelial neoplasia
…, CK Naughton, PA Humphrey, J Milbrandt - … and cellular biology, 2002 - Am Soc Microbiol
The homeodomain-containing transcription factor NKX3. 1 is a putative prostate tumor
suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss …
suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss …
DNA-binding specificity of NGFI-A and related zinc finger transcription factors
AH Swirnoff, J Milbrandt - Molecular and cellular biology, 1995 - Am Soc Microbiol
NGFI-A is the prototypic member of a family of immediate-early gene-encoded transcription
factors which includes NGFI-C, Egr3, and Krox20. These proteins possess highly …
factors which includes NGFI-C, Egr3, and Krox20. These proteins possess highly …
A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor
J Milbrandt - Science, 1987 - science.org
Nerve growth factor (NGF) is a trophic agent that promotes the outgrowth of nerve fibers from
sympathetic and sensory ganglia. The neuronal differentiation stimulated by this hormone …
sympathetic and sensory ganglia. The neuronal differentiation stimulated by this hormone …