User profiles for Jeff Milbrandt

Jeffrey Milbrandt

James S McDonnell Professor of Genetics, Washington University
Verified email at wustl.edu
Cited by 49967

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

T Araki, Y Sasaki, J Milbrandt - Science, 2004 - science.org
Axonal degeneration is an active program of self-destruction that is observed in many
physiological and pathological settings. In Wallerian degeneration slow (wld s ) mice, Wallerian …

Neurturin, a relative of glial-cell-line-derived neurotrophic factor

…, JP Golden, DJ Creedon, EM Johnson Jr, J Milbrandt - Nature, 1996 - nature.com
THE normal development of the vertebrate nervous system entails the death of 30–70% of the
neurons originally generated in most neuronal populations 1 . This naturally occurring cell …

Expression profiling reveals hepsin overexpression in prostate cancer

…, PA Humphrey, WJ Catalona, MA Watson, J Milbrandt - Cancer research, 2001 - AACR
Prostate cancer is the most commonly diagnosed noncutaneous cancer in men. Despite this
fact, many of the genetic changes that coincide with prostate cancer progression remain …

[HTML][HTML] FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression: implications for PTEN mutation in prostate cancer

V Modur, R Nagarajan, BM Evers, J Milbrandt - Journal of Biological …, 2002 - ASBMB
Mutations in PTEN occur in 60–80% of prostate cancers and lead to a constitutive activation
of the phosphatidylinositol 3-kinase pathway and a resultant loss of activity of the FOXO …

NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli

…, DB Zimonjic, NC Popescu, J Milbrandt - … and cellular biology, 1996 - Am Soc Microbiol
Previous work had identified a corepressor, NAB1, which represses transcriptional activation
mediated by NGFI-A (also known as Egr-1, zif268, and Krox24) and Krox20. These zinc …

Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons

…, L Simmons, E Johnson, J Milbrandt… - Journal of …, 1998 - Soc Neuroscience
Glial cell line-derived neurotrophic factor (GDNF) exhibits potent effects on survival and
function of midbrain dopaminergic (DA) neurons in a variety of models. Although other growth …

[PDF][PDF] Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons

…, A Bruce, RO Heuckeroth, EM Johnson, J Milbrandt - Neuron, 2002 - cell.com
Artemin (ARTN) is a member of the GDNF family of ligands and signals through the Ret/GFRα3
receptor complex. Characterization of ARTN- and GFRα3-deficient mice revealed similar …

Conditional loss of Nkx3. 1 in adult mice induces prostatic intraepithelial neoplasia

…, CK Naughton, PA Humphrey, J Milbrandt - … and cellular biology, 2002 - Am Soc Microbiol
The homeodomain-containing transcription factor NKX3. 1 is a putative prostate tumor
suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss …

DNA-binding specificity of NGFI-A and related zinc finger transcription factors

AH Swirnoff, J Milbrandt - Molecular and cellular biology, 1995 - Am Soc Microbiol
NGFI-A is the prototypic member of a family of immediate-early gene-encoded transcription
factors which includes NGFI-C, Egr3, and Krox20. These proteins possess highly …

A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor

J Milbrandt - Science, 1987 - science.org
Nerve growth factor (NGF) is a trophic agent that promotes the outgrowth of nerve fibers from
sympathetic and sensory ganglia. The neuronal differentiation stimulated by this hormone …