Airway epithelial cells in the lung are the first line of defense against pathogens and environmental
pollutants. Inhalation of the environmental pollutant cadmium has been linked to the …

Exposing mice to a social stressor called social disruption (SDR) that involves repeated
social defeat during intermale aggression results in increased circulating cytokines, such as …

Stress and glucocorticoid (GC) release are common behavioral and hormonal responses to
injury or disease. In the brain, stress/GCs can alter neuron structure and function leading to …

Respiratory syncytial virus (RSV) is a common cause of bronchiolitis in infants. Although
antiinflammatory in nature, glucocorticoids have been shown to be ineffective in the treatment of …

Over the past 20 years we have demonstrated both in animal models and in human studies
that stress increases neuroendocrine hormones, particularly glucocorticoids and …

Studies suggest that stress can be a co-factor for the initiation and progression of cancer. The
catecholamine stress hormone, norepinephrine (NE), may influence tumor progression by …

Psychological stress-associated immune dysregulation has been shown to disrupt the
steady-state expression and reactivate latent herpes viruses. One such virus is the Epstein Barr …

The hypothalamic-pituitary-adrenal (HPA) axis activation and glucocorticoid responses are
critical for survival from a number of bacterial, viral and toxic insults, demonstrated by the fact …

Respiratory syncytial virus (RSV)-induced bronchiolitis in infants is not responsive to
glucocorticoids. We have shown that RSV infection impairs glucocorticoid receptor (GR) function. In …

Purpose Glucocorticoids are commonly prescribed to treat a number of diseases including
the majority of inflammatory diseases. Despite considerable interpersonal variability in …