User profiles for Jane Y. Chen
Jane Y ChenUniversity of Washington Verified email at uw.edu Cited by 1188 |
[PDF][PDF] Polony gels enable amplifiable DNA stamping and spatial transcriptomics of chronic pain
Methods for acquiring spatially resolved omics data from complex tissues use barcoded
DNA arrays of low- to sub-micrometer features to achieve single-cell resolution. However, …
DNA arrays of low- to sub-micrometer features to achieve single-cell resolution. However, …
[HTML][HTML] Dopamine imbalance in Huntington's disease: a mechanism for the lack of behavioral flexibility
Dopamine (DA) plays an essential role in the control of coordinated movements. Alterations
in DA balance in the striatum lead to pathological conditions such as Parkinson's and …
in DA balance in the striatum lead to pathological conditions such as Parkinson's and …
Multiple sources of striatal inhibition are differentially affected in Huntington's disease mouse models
…, SP Rao, VM André, EP Botelho, JY Chen… - Journal of …, 2013 - Soc Neuroscience
In Huntington's disease (HD) mouse models, spontaneous inhibitory synaptic activity is
enhanced in a subpopulation of medium-sized spiny neurons (MSNs), which could dampen …
enhanced in a subpopulation of medium-sized spiny neurons (MSNs), which could dampen …
[PDF][PDF] Parabrachial CGRP neurons establish and sustain aversive taste memories
Food aversions develop when the taste of a novel food is associated with sickness, which
often occurs after food poisoning or chemotherapy treatment. We identified calcitonin-gene-…
often occurs after food poisoning or chemotherapy treatment. We identified calcitonin-gene-…
Molecular and anatomical characterization of parabrachial neurons and their axonal projections
The parabrachial nucleus (PBN) is a major hub that receives sensory information from both
internal and external environments. Specific populations of PBN neurons are involved in …
internal and external environments. Specific populations of PBN neurons are involved in …
Cholesterol‐loaded nanoparticles ameliorate synaptic and cognitive function in H untington's disease mice
Brain cholesterol biosynthesis and cholesterol levels are reduced in mouse models of
Huntington's disease ( HD ), suggesting that locally synthesized, newly formed cholesterol is less …
Huntington's disease ( HD ), suggesting that locally synthesized, newly formed cholesterol is less …
Dissociable control of unconditioned responses and associative fear learning by parabrachial CGRP neurons
Parabrachial CGRP neurons receive diverse threat-related signals and contribute to
multiple phases of adaptive threat responses in mice, with their inactivation attenuating both …
multiple phases of adaptive threat responses in mice, with their inactivation attenuating both …
Continuous polony gels for tissue mapping with high resolution and RNA capture efficiency
Current technologies for acquiring spatial transcript information from tissue sections rely on
either RNA probes or spatial barcodes. The former methods require a priori knowledge for …
either RNA probes or spatial barcodes. The former methods require a priori knowledge for …
Pacemaker GABA synaptic activity may contribute to network synchronization in pediatric cortical dysplasia
Spontaneous pacemaker γ-aminobutyric acid (GABA) receptor-mediated synaptic activity (PGA)
occurs in a subset of tissue samples from pediatric epilepsy surgery patients. In the …
occurs in a subset of tissue samples from pediatric epilepsy surgery patients. In the …
[HTML][HTML] Satb2 neurons in the parabrachial nucleus mediate taste perception
The neural circuitry mediating taste has been mapped out from the periphery to the cortex,
but genetic identity of taste-responsive neurons has remained elusive. Here, we describe a …
but genetic identity of taste-responsive neurons has remained elusive. Here, we describe a …