User profiles for Jane Y. Chen

Jane Y Chen

University of Washington
Verified email at uw.edu
Cited by 1188

[PDF][PDF] Polony gels enable amplifiable DNA stamping and spatial transcriptomics of chronic pain

…, L Sun, R Dong, JY Chen, R Silakit, LF Condon, Y Lin… - Cell, 2022 - cell.com
Methods for acquiring spatially resolved omics data from complex tissues use barcoded
DNA arrays of low- to sub-micrometer features to achieve single-cell resolution. However, …

[HTML][HTML] Dopamine imbalance in Huntington's disease: a mechanism for the lack of behavioral flexibility

JY Chen, EA Wang, C Cepeda… - Frontiers in neuroscience, 2013 - frontiersin.org
Dopamine (DA) plays an essential role in the control of coordinated movements. Alterations
in DA balance in the striatum lead to pathological conditions such as Parkinson's and …

Multiple sources of striatal inhibition are differentially affected in Huntington's disease mouse models

…, SP Rao, VM André, EP Botelho, JY Chen… - Journal of …, 2013 - Soc Neuroscience
In Huntington's disease (HD) mouse models, spontaneous inhibitory synaptic activity is
enhanced in a subpopulation of medium-sized spiny neurons (MSNs), which could dampen …

[PDF][PDF] Parabrachial CGRP neurons establish and sustain aversive taste memories

JY Chen, CA Campos, BC Jarvie, RD Palmiter - Neuron, 2018 - cell.com
Food aversions develop when the taste of a novel food is associated with sickness, which
often occurs after food poisoning or chemotherapy treatment. We identified calcitonin-gene-…

Molecular and anatomical characterization of parabrachial neurons and their axonal projections

JL Pauli, JY Chen, ML Basiri, S Park, ME Carter… - Elife, 2022 - elifesciences.org
The parabrachial nucleus (PBN) is a major hub that receives sensory information from both
internal and external environments. Specific populations of PBN neurons are involved in …

Cholesterol‐loaded nanoparticles ameliorate synaptic and cognitive function in H untington's disease mice

M Valenza, JY Chen, E Di Paolo, B Ruozi… - EMBO molecular …, 2015 - embopress.org
Brain cholesterol biosynthesis and cholesterol levels are reduced in mouse models of
Huntington's disease ( HD ), suggesting that locally synthesized, newly formed cholesterol is less …

Dissociable control of unconditioned responses and associative fear learning by parabrachial CGRP neurons

AJ Bowen, JY Chen, YW Huang, NA Baertsch, S Park… - Elife, 2020 - elifesciences.org
Parabrachial CGRP neurons receive diverse threat-related signals and contribute to
multiple phases of adaptive threat responses in mice, with their inactivation attenuating both …

Continuous polony gels for tissue mapping with high resolution and RNA capture efficiency

X Fu, L Sun, JY Chen, R Dong, Y Lin, RD Palmiter… - BioRxiv, 2021 - biorxiv.org
Current technologies for acquiring spatial transcript information from tissue sections rely on
either RNA probes or spatial barcodes. The former methods require a priori knowledge for …

Pacemaker GABA synaptic activity may contribute to network synchronization in pediatric cortical dysplasia

C Cepeda, JY Chen, JY Wu, RS Fisher, HV Vinters… - Neurobiology of …, 2014 - Elsevier
Spontaneous pacemaker γ-aminobutyric acid (GABA) receptor-mediated synaptic activity (PGA)
occurs in a subset of tissue samples from pediatric epilepsy surgery patients. In the …

[HTML][HTML] Satb2 neurons in the parabrachial nucleus mediate taste perception

BC Jarvie, JY Chen, HO King, RD Palmiter - Nature communications, 2021 - nature.com
The neural circuitry mediating taste has been mapped out from the periphery to the cortex,
but genetic identity of taste-responsive neurons has remained elusive. Here, we describe a …