Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan (CSPG)-containing
structures that surround the soma and dendrites of various mammalian …

Damage to the central nervous system (CNS) results in a glial reaction, leading eventually to
the formation of a glial scar. In this environment, axon regeneration fails, and remyelination …

Following CNS injury in the adult mammal, axon regeneration fails in scar regions containing
a number of different chondroitin sulfate-bearing proteoglycans (CSPGs) 1. Degradation of …

The inability of axons to regenerate after a spinal cord injury in the adult mammalian central
nervous system (CNS) can lead to permanent paralysis. At sites of CNS injury, a glial scar …

In young animals, monocular deprivation leads to an ocular dominance shift, whereas in
adults after the critical period there is no such shift. Chondroitin sulphate proteoglycans (CSPGs…

Chondroitin sulfate proteoglycans (CSPGs) consist of a core protein and glycosaminoglycan
(GAG) chains. There is enormous structural diversity among CSPGs due to variation in the …

Adult mammalian central nervous system axons have intrinsically poor regenerative capacity,
so axonal injury has permanent consequences. One approach to enhancing regeneration …

The development of most regions of the vertebrate nervous system includes a distinct phase
of neuronal degeneration during which a substantial proportion of the neurons initially …

Injury to the CNS results in the formation of the glial scar, a primarily astrocytic structure that
represents an obstacle to regrowing axons. Chondroitin sulfate proteoglycans (CSPG) are …

Publisher Summary This chapter focuses on the changes in the expression of the axon
growth-inhibitory chondroitin sulphate proteoglycans (CSPGs). CSPGs represent a varied class …