User profiles for James David Jentsch

J. David Jentsch

Binghamton University
Verified email at binghamton.edu
Cited by 14847

Dissecting impulsivity and its relationships to drug addictions

JD Jentsch, JR Ashenhurst… - Annals of the New …, 2014 - Wiley Online Library
Addictions are often characterized as forms of impulsive behavior. That said, it is often noted
that impulsivity is a multidimensional construct, spanning several psychological domains. …

Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli

JD Jentsch, JR Taylor - Psychopharmacology, 1999 - Springer
Drug abuse and dependence define behavioral states involving increased allocation of
behavior towards drug seeking and taking at the expense of more appropriate behavioral …

[HTML][HTML] The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia

JD Jentsch, RH Roth - Neuropsychopharmacology, 1999 - Elsevier
Administration of noncompetitive NMDA/glutamate receptor antagonists, such as
phencyclidine (PCP) and ketamine, to humans induces a broad range of schizophrenic-like …

Reversal learning as a measure of impulsive and compulsive behavior in addictions

A Izquierdo, JD Jentsch - Psychopharmacology, 2012 - Springer
Background Our ability to measure the cognitive components of complex decision-making
across species has greatly facilitated our understanding of its neurobiological mechanisms. …

Insight into the relationship between impulsivity and substance abuse from studies using animal models

…, P Olausson, JR Taylor, JD Jentsch - Alcoholism: Clinical …, 2010 - Wiley Online Library
Drug use disorders are often accompanied by deficits in the capacity to efficiently process
reward‐related information and to monitor, suppress, or override reward‐controlled behavior …

Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine

JD Jentsch, DE Redmond Jr, JD Elsworth, JR Taylor… - Science, 1997 - science.org
The effects of the psychotomimetic drug phencyclidine on the neurochemistry and function
of the prefrontal cortex in vervet monkeys were investigated. Monkeys treated with …

Poor response inhibition: at the nexus between substance abuse and attention deficit/hyperactivity disorder

SM Groman, AS James, JD Jentsch - Neuroscience & Biobehavioral …, 2009 - Elsevier
The co-morbidity between attention deficit hyperactivity disorder (ADHD) and substance abuse
and dependence disorders may have multiple causes and consequences. In this review, …

[PDF][PDF] The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1

W Li, Y Cui, SA Kushner, RAM Brown, JD Jentsch… - Current Biology, 2005 - cell.com
Neurofibromatosis Type 1 (NF1) is a common neurological disorder caused by mutations in
the gene encoding Neurofibromin, a p21Ras GTPase Activating Protein (GAP) [1]. …

Neurofibromin regulates corticostriatal inhibitory networks during working memory performance

…, M Hardt, AS James, D Ehninger… - Proceedings of the …, 2010 - National Acad Sciences
Neurofibromatosis type I (NF1) is one of the most common single-gene causes of learning
disabilities. Here, we use behavioral working memory probes and electrophysiological studies …

Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward

…, C Cepeda, BL Kieffer, MS Levine, JD Jentsch… - Nature …, 2014 - nature.com
μ-opioid receptors (MORs) are necessary for the analgesic and addictive effects of opioids
such as morphine, but the MOR-expressing neuronal populations that mediate the distinct …