Cancer cells exploit the expression of the programmed death-1 (PD-1) ligand 1 (PD-L1) to
subvert T-cell-mediated immunosurveillance 1 , 2 . The success of therapies that disrupt PD-…

Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous
system (CNS) diseases. Although the replacement of lost endogenous cells was originally …

Background. Over half of new cancer cases occur in patients aged ≥65 years. Many older
patients can benefit from intensive cancer therapies, yet evidence suggests that this …

Purpose Even with the dissemination of several clinical guidelines, chronic obstructive
pulmonary disease (COPD) remains underdiagnosed and mismanaged by many primary care …

The outcome of infection is dependent on the ability of viruses to manipulate the infected
cell to evade immunity, and the ability of the immune response to overcome this evasion. …

10.7554/eLife.18296.001 Viruses manipulate host factors to enhance their replication and
evade cellular restriction. We used multiplex tandem mass tag (TMT)-based whole cell …

HIV-1 encodes four "accessory proteins" (Vif, Vpr, Vpu, and Nef), dispensable for viral
replication in vitro but essential for viral pathogenesis in vivo. Well characterized cellular targets …

We present basic workups and quantitative comparisons for two current generation Orbitrap
mass spectrometers, the Q Exactive Plus and Orbitrap Fusion Tribrid, which are widely …

The HUSH complex represses retroviruses, transposons and genes to maintain the integrity
of vertebrate genomes. HUSH regulates deposition of the epigenetic mark H3K9me3, but …

Misfolded or damaged proteins are typically targeted for destruction by proteasome‐mediated
degradation, but the mammalian ubiquitin machinery involved is incompletely understood. …