REDD1 is essential for stress-induced synaptic loss and depressive behavior
KT Ota, RJ Liu, B Voleti, JG Maldonado-Aviles… - Nature medicine, 2014 - nature.com
Major depressive disorder (MDD) affects up to 17% of the population, causing profound
personal suffering and economic loss 1 . Clinical and preclinical studies have revealed that …
personal suffering and economic loss 1 . Clinical and preclinical studies have revealed that …
Characterization of GABAergic marker expression in the chronic unpredictable stress model of depression
…, C Fee, V Duric, J Maldonado-Aviles… - Chronic …, 2017 - journals.sagepub.com
Background Evidence continues to build suggesting that the GABAergic neurotransmitter
system is altered in brains of patients with major depressive disorder. However, there is little …
system is altered in brains of patients with major depressive disorder. However, there is little …
Altered markers of tonic inhibition in the dorsolateral prefrontal cortex of subjects with schizophrenia
JG Maldonado-Avilés, AA Curley… - American Journal of …, 2009 - Am Psychiatric Assoc
Objective: Cognitive impairments in schizophrenia are associated with lower expression of
markers of γ-aminobutyric acid (GABA) synthesis in the prefrontal cortex. The effects of GABA …
markers of γ-aminobutyric acid (GABA) synthesis in the prefrontal cortex. The effects of GABA …
Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding
…, D Mestivier, B Finan, JG Maldonado-Aviles… - Molecular …, 2014 - nature.com
Circulating triglycerides (TGs) normally increase after a meal but are altered in pathophysiological
conditions, such as obesity. Although TG metabolism in the brain remains poorly …
conditions, such as obesity. Although TG metabolism in the brain remains poorly …
Ribosomal protein S6 kinase 1 signaling in prefrontal cortex controls depressive behavior
JM Dwyer, JG Maldonado-Avilés… - Proceedings of the …, 2015 - National Acad Sciences
Current treatments for major depressive disorder (MDD) have a time lag and are ineffective
for a large number of patients. Development of novel pharmacological therapies requires a …
for a large number of patients. Development of novel pharmacological therapies requires a …
Vitamin D3: a role in dopamine circuit regulation, diet-induced obesity, and drug consumption
…, RJ Wickham, LA Tellez, J Maldonado-Aviles… - Eneuro, 2016 - eneuro.org
The influence of micronutrients on dopamine systems is not well defined. Using mice, we
show a potential role for reduced dietary vitamin D3 (cholecalciferol) in promoting diet-induced …
show a potential role for reduced dietary vitamin D3 (cholecalciferol) in promoting diet-induced …
Gene profiling reveals a role for stress hormones in the molecular and behavioral response to food restriction
…, CE Brayton, SM Richards, J Maldonado-Aviles… - Biological …, 2012 - Elsevier
BACKGROUND: Food restriction is known to enhance learning and motivation. The neural
mechanisms underlying these responses likely involve alterations in gene expression in …
mechanisms underlying these responses likely involve alterations in gene expression in …
Down-regulation of miRNAs in the brain and development of diet-induced obesity
JG Maldonado-Avilés, DJ Guarnieri, X Zhu… - International Journal of …, 2018 - Elsevier
Novel therapeutic interventions for obesity and comorbid conditions require knowledge of
the molecular elements playing a role in the development of obesity. Chronic low-grade …
the molecular elements playing a role in the development of obesity. Chronic low-grade …
Somal size of immunolabeled pyramidal cells in the prefrontal cortex of subjects with schizophrenia
JG Maldonado-Avilés, Q Wu, AR Sampson… - Biological psychiatry, 2006 - Elsevier
BACKGROUND: Although the somal volume of Nissl-stained deep layer 3 pyramidal cells is
reduced in prefrontal cortex area 9 of subjects with schizophrenia, the subset of large …
reduced in prefrontal cortex area 9 of subjects with schizophrenia, the subset of large …
Inhaling: endocannabinoids and food intake
JG Maldonado-Aviles, RJ DiLeone - Nature Neuroscience, 2014 - nature.com
… Maldonado-Avilés and Ralph J. DiLeone are in the Department of Psychiatry, Yale
University School of Medicine, New Haven, Connecticut, USA., Jaime G Maldonado-Avilés …
University School of Medicine, New Haven, Connecticut, USA., Jaime G Maldonado-Avilés …