Objective: Cognitive decline accompanies acute illness and surgery, especially in the
elderly. Surgery engages the innate immune system that launches a systemic inflammatory …

Blood-brain barrier disruption, microglial activation and neurodegeneration are hallmarks of
multiple sclerosis. However, the initial triggers that activate innate immune responses and …

The blood coagulation protein fibrinogen is deposited in the brain in a wide range of
neurological diseases and traumatic injuries with blood–brain barrier (BBB) disruption. Recent …

Blood protein extravasation through a disrupted blood–brain barrier and innate immune
activation are hallmarks of neurological diseases and emerging therapeutic targets. However, …

Metabolism has been shown to integrate with epigenetics and transcription to modulate cell
fate and function 1 , 2 , 3 . Beyond meeting the bioenergetic and biosynthetic demands of T-…

Cerebrovascular alterations are a key feature of Alzheimer's disease (AD) pathogenesis.
However, whether vascular damage contributes to synaptic dysfunction and how it synergizes …

Autoimmunity and macrophage recruitment into the central nervous system (CNS) are
critical determinants of neuroinflammatory diseases. However, the mechanisms that drive …

Oxidative stress is a central part of innate immune-induced neurodegeneration. However,
the transcriptomic landscape of central nervous system (CNS) innate immune cells …

Blood-brain barrier (BBB) disruption alters the composition of the brain microenvironment by
allowing blood proteins into the CNS. However, whether blood-derived molecules serve as …

The balance of effector and regulatory T cell function, dependent on multiple signals and
epigenetic regulators, is critical to immune self-tolerance. Dysregulation of T helper 17 (Th17) …