Advances in the development of biomarkers for epilepsy

…, K Lukasiuk, O Gröhn, JP Bankstahl… - The Lancet …, 2016 - thelancet.com
Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy
remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs. …

Myocardial inflammation predicts remodeling and neuroinflammation after myocardial infarction

JT Thackeray, HC Hupe, Y Wang, JP Bankstahl… - Journal of the American …, 2018 - jacc.org
Background : The local inflammatory tissue response after acute myocardial infarction (MI)
determines subsequent healing. Systemic interaction may induce neuroinflammation as a …

Pgp‐Mediated Interaction Between (R)‐[11C]Verapamil and Tariquidar at the Human Blood–Brain Barrier: A Comparison With Rat Data

…, M Mitterhauser, JP Bankstahl… - Clinical …, 2012 - Wiley Online Library
Using positron emission tomography (PET) imaging we assessed, in vivo, the interaction
between a microdose of (R)‐[ 11 C]verapamil (a P‐glycoprotein (Pgp) substrate) and escalating …

Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis

…, A Mirenska, C Hennig, T Rodt, JP Bankstahl… - Science translational …, 2014 - science.org
Hereditary pulmonary alveolar proteinosis (herPAP) is a rare lung disease caused by
mutations in the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor genes, …

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[11C]verapamil …

C Kuntner, JP Bankstahl, M Bankstahl, J Stanek… - European journal of …, 2010 - Springer
Purpose Overactivity of the multidrug efflux transporter P-glycoprotein (P-gp) at the blood-brain
barrier (BBB) is believed to play an important role in resistance to central nervous system …

Tariquidar-induced P-glycoprotein inhibition at the rat blood–brain barrier studied with (R)-11C-verapamil and PET

JP Bankstahl, C Kuntner, A Abrahim… - Journal of Nuclear …, 2008 - Soc Nuclear Med
The multidrug efflux transporter P-glycoprotein (P-gp) is expressed in high concentrations at
the blood–brain barrier (BBB) and is believed to be implicated in resistance to central …

Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in …

JP Bankstahl, M Bankstahl, K Römermann… - Drug Metabolism and …, 2013 - ASPET
Elacridar (ELC) and tariquidar (TQD) are generally thought to be nontransported inhibitors of
P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP), but recent data indicate …

[HTML][HTML] Imaging of chemokine receptor CXCR4 expression in culprit and nonculprit coronary atherosclerotic plaque using motion-corrected [68Ga]pentixafor PET/CT

…, S Kropf, JT Thackeray, JP Bankstahl… - European journal of …, 2018 - Springer
Purpose The chemokine receptor CXCR4 is a promising target for molecular imaging of
CXCR4 + cell types, eg inflammatory cells, in cardiovascular diseases. We speculated that a …

Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain

JP Bankstahl, K Hoffmann, K Bethmann, W Löscher - Neuropharmacology, 2008 - Elsevier
About 30% of patients with epilepsy do not respond adequately to drug therapy, making
pharmacoresistance a major problem in the treatment of this common brain disorder. …

Isoflurane prevents acquired epilepsy in rat models of temporal lobe epilepsy

…, K Töllner, H Dalipaj, JP Bankstahl… - Annals of …, 2016 - Wiley Online Library
Objective Acquired epilepsy is a devastating long‐term risk of various brain insults, including
trauma, stroke, infections, and status epilepticus (SE). There is no preventive treatment for …