User profiles for J. J. Palop
 | Jorge J Palop, PhDAssociate Professor of Neurology, Gladstone Institutes; University of California, San … Verified email at gladstone.ucsf.edu Cited by 16287 |
Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
Alzheimer's disease is the most frequent neurodegenerative disorder and the most common
cause of dementia in the elderly. Diverse lines of evidence suggest that amyloid-β (Aβ) …
cause of dementia in the elderly. Diverse lines of evidence suggest that amyloid-β (Aβ) …
Network abnormalities and interneuron dysfunction in Alzheimer disease
The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …
Epilepsy and cognitive impairments in Alzheimer disease
Alzheimer disease (AD) is associated with cognitive decline and increased incidence of
seizures. Seizure activity in AD has been widely interpreted as a secondary process resulting …
seizures. Seizure activity in AD has been widely interpreted as a secondary process resulting …
Reducing endogenous tau ameliorates amyloid ß-induced deficits in an Alzheimer's disease mouse model
Many potential treatments for Alzheimer's disease target amyloid-β peptides (Aβ), which are
widely presumed to cause the disease. The microtubule-associated protein tau is also …
widely presumed to cause the disease. The microtubule-associated protein tau is also …
[HTML][HTML] Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
Neural network dysfunction may play an important role in Alzheimer's disease (AD).
Neuronal circuits vulnerable to AD are also affected in human amyloid precursor protein (hAPP) …
Neuronal circuits vulnerable to AD are also affected in human amyloid precursor protein (hAPP) …
[HTML][HTML] Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model
Alzheimer's disease (AD) results in cognitive decline and altered network activity, but the
mechanisms are unknown. We studied human amyloid precursor protein (hAPP) transgenic …
mechanisms are unknown. We studied human amyloid precursor protein (hAPP) transgenic …
A network dysfunction perspective on neurodegenerative diseases
Patients with Alzheimer's disease or other neurodegenerative disorders show remarkable
fluctuations in neurological functions, even during the same day. These fluctuations cannot be …
fluctuations in neurological functions, even during the same day. These fluctuations cannot be …
Amyloid-β/Fyn–induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease
…, P Hamto, N Devidze, GQ Yu, JJ Palop… - Journal of …, 2011 - Soc Neuroscience
Alzheimer's disease (AD), the most common neurodegenerative disorder, is a growing
public health problem and still lacks effective treatments. Recent evidence suggests that …
public health problem and still lacks effective treatments. Recent evidence suggests that …
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model
In light of the rising prevalence of Alzheimer’s disease (AD), new strategies to prevent, halt,
and reverse this condition are needed urgently. Perturbations of brain network activity are …
and reverse this condition are needed urgently. Perturbations of brain network activity are …
[HTML][HTML] Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models
Many proteins suspected of causing neurodegenerative diseases exist in diverse assembly
states. For most, it is unclear whether shifts from one state to another would be helpful or …
states. For most, it is unclear whether shifts from one state to another would be helpful or …