Understanding the cellular and molecular mechanisms underlying the formation and
maintenance of memories is a central goal of the neuroscience community. It is well regarded that …

One of the most exciting discoveries in the learning and memory field in the past two decades
is the observation that active regulation of gene expression is necessary for experience to …

Memory formation is a multi-stage process that initially requires cellular consolidation in the
hippocampus, after which memories are downloaded to the cortex for maintenance, in a …

Histone variants were recently discovered to regulate neural plasticity, with H2A.Z emerging
as a memory suppressor. Using whole-genome sequencing of the mouse hippocampus, we …

Post-traumatic stress disorder (PTSD) is a psychiatric condition characterized by intrusive
and persistent memories of a psychologically traumatic event that leads to significant …

The neuronal epigenome is highly sensitive to external events and its function is vital for
producing stable behavioral outcomes, such as the formation of long-lasting memories. The …

Emerging evidence suggests that histone variants are novel epigenetic regulators of memory,
whereby histone H2A.Z suppresses fear memory. However, it is not clear if altered fear …

Memory formation is a protracted process that initially involves the hippocampus and becomes
increasingly dependent on the cortex over time, but the mechanisms of this transfer are …

Highlights • New evidence shows that chromatin regulation is highly dynamic during memory
formation. • Chromatin is modified by incorporating functionally distinct histone variants to …

Histone variants H2A.Z and H3.3 are epigenetic regulators of memory, but roles of other
variants are not well characterized. macroH2A (mH2A) is a structurally unique histone that …