User profiles for Irakli Intskirveli
Irakli IntskirveliPhD in Neuroscience, UCI Verified email at uci.edu Cited by 893 |
When pliers become fingers in the monkey motor system
MA Umiltà, L Escola, I Intskirveli… - Proceedings of the …, 2008 - National Acad Sciences
The capacity to use tools is a fundamental evolutionary achievement. Its essence stands in
the capacity to transfer a proximal goal (grasp a tool) to a distal goal (eg, grasp food). Where …
the capacity to transfer a proximal goal (grasp a tool) to a distal goal (eg, grasp food). Where …
[HTML][HTML] Responses of mirror neurons in area F5 to hand and tool grasping observation
Mirror neurons are a distinct class of neurons that discharge both during the execution of a
motor act and during observation of the same or similar motor act performed by another …
motor act and during observation of the same or similar motor act performed by another …
Nicotinic neuromodulation in auditory cortex requires MAPK activation in thalamocortical and intracortical circuits
I Intskirveli, R Metherate - Journal of Neurophysiology, 2012 - journals.physiology.org
Activation of nicotinic acetylcholine receptors (nAChRs) by systemic nicotine enhances
sensory-cognitive function and sensory-evoked cortical responses. Although nAChRs mediate …
sensory-cognitive function and sensory-evoked cortical responses. Although nAChRs mediate …
[HTML][HTML] Nicotinic filtering of sensory processing in auditory cortex
R Metherate, I Intskirveli, HD Kawai - Frontiers in behavioral …, 2012 - frontiersin.org
Although it has been known for decades that the drug nicotine can improve cognitive function,
the nature of its effects and the underlying mechanisms are not well understood. Nicotine …
the nature of its effects and the underlying mechanisms are not well understood. Nicotine …
Systemic nicotine increases gain and narrows receptive fields in A1 via integrated cortical and subcortical actions
C Askew, I Intskirveli, R Metherate - eneuro, 2017 - eneuro.org
Nicotine enhances sensory and cognitive processing via actions at nicotinic acetylcholine
receptors (nAChRs), yet the precise circuit- and systems-level mechanisms remain unclear. In …
receptors (nAChRs), yet the precise circuit- and systems-level mechanisms remain unclear. In …
Tone-detection training enhances spectral integration mediated by intracortical pathways in primary auditory cortex
Auditory-cued behavioral training can alter neural circuits in primary auditory cortex (A1), but
the mechanisms and consequences of experience-dependent cortical plasticity are not fully …
the mechanisms and consequences of experience-dependent cortical plasticity are not fully …
Spectral breadth and laminar distribution of thalamocortical inputs to A1
I Intskirveli, A Joshi… - Journal of …, 2016 - journals.physiology.org
The GABAergic agonist muscimol is used to inactivate brain regions in order to reveal
afferent inputs in isolation. However, muscimol's use in primary auditory cortex (A1) has been …
afferent inputs in isolation. However, muscimol's use in primary auditory cortex (A1) has been …
[HTML][HTML] Null mutations in EphB receptors decrease sharpness of frequency tuning in primary auditory cortex
Primary auditory cortex (A1) exhibits a tonotopic representation of characteristic frequency (CF).
The receptive field properties of A1 neurons emerge from a combination of thalamic …
The receptive field properties of A1 neurons emerge from a combination of thalamic …
Development of fluorescence imaging probes for nicotinic acetylcholine α4β2∗ receptors
GK Samra, I Intskirveli, AP Govind, C Liang… - Bioorganic & medicinal …, 2018 - Elsevier
Nicotinic acetylcholine α4β2 ∗ receptors (nAChRs) are implicated in various neurodegenerative
diseases and smoking addiction. Imaging of brain high-affinity α4β2 ∗ nAChRs at the …
diseases and smoking addiction. Imaging of brain high-affinity α4β2 ∗ nAChRs at the …
[HTML][HTML] Nicotine enhances amplitude and consistency of timing of responses to acoustic trains in A1
I Intskirveli, R Metherate - Frontiers in Neural Circuits, 2021 - frontiersin.org
Systemic nicotine enhances neural processing in primary auditory cortex (A1) as determined
using tone-evoked, current-source density (CSD) measurements. For example, nicotine …
using tone-evoked, current-source density (CSD) measurements. For example, nicotine …