Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c

YC Chen, HY Kuo, U Bornschein, H Takahashi… - Nature …, 2016 - nature.com
Cortico-basal ganglia circuits are critical for speech and language and are implicated in autism
spectrum disorder, in which language function can be severely affected. We demonstrate …

Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons

HY Kuo, SY Chen, RC Huang, H Takahashi, YH Lee… - Brain, 2023 - academic.oup.com
Human speech and language are among the most complex motor and cognitive abilities.
The discovery of a mutation in the transcription factor FOXP2 in KE family members with …

[HTML][HTML] Molecular pathology and pharmacological treatment of autism spectrum disorder-like phenotypes using rodent models

HY Kuo, FC Liu - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder with a
high prevalence rate. The core symptoms of ASD patients are impaired social communication …

Valproic acid induces aberrant development of striatal compartments and corticostriatal pathways in a mouse model of autism spectrum disorder

HY Kuo, FC Liu - The FASEB Journal, 2017 - Wiley Online Library
The striatum comprises two neurochemical compartments: striosomes and the matrix. Striosomal
and matrix compartments receive inputs from limbic system‐related and sensorimotor …

Synaptic wiring of corticostriatal circuits in basal ganglia: insights into the pathogenesis of neuropsychiatric disorders

HY Kuo, FC Liu - eneuro, 2019 - eneuro.org
The striatum is a key hub in the basal ganglia for processing neural information from the
sensory, motor, and limbic cortices. The massive and diverse cortical inputs entering the …

[HTML][HTML] Pathophysiological studies of monoaminergic neurotransmission systems in valproic acid-induced model of autism spectrum disorder

HY Kuo, FC Liu - Biomedicines, 2022 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex etiology.
The core syndromes of ASD are deficits in social communication and self-restricted interests …

Differential and overlapping pattern of Foxp1 and Foxp2 expression in the striatum of adult mouse brain

WL Fong, HY Kuo, HL Wu, SY Chen, FC Liu - Neuroscience, 2018 - Elsevier
Genetic mutations of FOXP1 and FOXP2 are associated with neurodevelopmental diseases.
It is important to characterize the cell types that express Foxp1 and Foxp2 in the brain. …

Diversity of sexual activity and correlates among women with gynecological cancer

JT Lee, HY Kuo, KG Huang, JR Lin, ML Chen - Gynecologic Oncology, 2020 - Elsevier
Objective Sexual dysfunction has been reported in women following treatment for gynecological
cancer. However, the actual sexual activities adopted by these women are not well …

[HTML][HTML] Pathological alterations in striatal compartments in the human brain of autism spectrum disorder

HY Kuo, FC Liu - Molecular brain, 2020 - Springer
The striatum comprises a mosaic structure of striosomal and matrix compartments. Imbalanced
neuronal activity between striosomes and matrix is implicated in neurological deficits in …

Differential development of dendritic spines in striatal projection neurons of direct and indirect pathways in the caudoputamen and nucleus accumbens

HY Kuo, YH Yang, SY Chen, TH Kuo, WT Lin, FC Liu - Eneuro, 2023 - eneuro.org
Synaptic modification in postnatal development is essential for the maturation of neural
networks. Developmental maturation of excitatory synapses occurs at the loci of dendritic spines …