Prioritized experience replays on a hippocampal predictive map for learning
Hippocampal cells are central to spatial and predictive representations, and experience
replays by place cells are crucial for learning and memory. Nonetheless, how hippocampal …
replays by place cells are crucial for learning and memory. Nonetheless, how hippocampal …
[HTML][HTML] Machine learning-based prediction of adverse drug effects: an example of seizure-inducing compounds
M Gao, H Igata, A Takeuchi, K Sato… - Journal of pharmacological …, 2017 - Elsevier
Various biological factors have been implicated in convulsive seizures, involving side effects
of drugs. For the preclinical safety assessment of drug development, it is difficult to predict …
of drugs. For the preclinical safety assessment of drug development, it is difficult to predict …
[PDF][PDF] The integration of goal-directed signals onto spatial maps of hippocampal place cells
Spatial firing of hippocampal place cells varies depending on the animal's behavior relative
to its goals. Here, rats were trained to approach visually guided reward ports in a two-…
to its goals. Here, rats were trained to approach visually guided reward ports in a two-…
[HTML][HTML] Spatial representation of hippocampal place cells in a T-maze with an aversive stimulation
The hippocampus contains place cells representing spaces in an environment, and these
place cells have been suggested to play a fundamental role in the formation of a cognitive …
place cells have been suggested to play a fundamental role in the formation of a cognitive …
[PDF][PDF] Awake hippocampal synchronous events are incorporated into offline neuronal reactivation
Learning novel experiences reorganizes hippocampal neuronal circuits, represented as
coordinated reactivation patterns in post-experience offline states for memory consolidation. …
coordinated reactivation patterns in post-experience offline states for memory consolidation. …
[HTML][HTML] A new device for the simultaneous recording of cerebral, cardiac, and muscular electrical activity in freely moving rodents
S Okada, H Igata, T Sakaguchi, T Sasaki… - Journal of …, 2016 - Elsevier
We present a new technique for the simultaneous capture of bioelectrical time signals from
the brain and peripheral organs of freely moving rodents. The recording system integrates all …
the brain and peripheral organs of freely moving rodents. The recording system integrates all …
Multiple cancer type classification by small RNA expression profiles with plasma samples from multiple facilities
K Suzuki, H Igata, M Abe, Y Yamamoto… - Cancer …, 2022 - Wiley Online Library
Liquid biopsy is expected to be a promising cancer screening method because of its low
invasiveness and the possibility of detecting multiple types in a single test. In the last decade, …
invasiveness and the possibility of detecting multiple types in a single test. In the last decade, …
Time‐varying synchronous cell ensembles during consummatory periods correlate with variable numbers of place cell spikes
Spike rates of a hippocampal place cell are not constant and vary even when an animal visits
an identical place field with nearly identical behavior. As one potential neurophysiological …
an identical place field with nearly identical behavior. As one potential neurophysiological …
The pharmacological assessment of GABAA receptor activation in experimental febrile seizures in mice
Hyperthermia-induced febrile seizures (FSs) are the most common seizures during childhood,
and prolonged complex FSs can result in the development of epilepsy. Currently, GABA A …
and prolonged complex FSs can result in the development of epilepsy. Currently, GABA A …
[HTML][HTML] Selective attenuation of electrophysiological activity of the dentate gyrus in a social defeat mouse model
…, Y Nishimura, T Hondrich, R Nakayama, H Igata… - The journal of …, 2017 - Springer
Current research on stress pathology has revealed a set of molecular and cellular mechanisms
through which psychosocial stress impairs brain function. However, there are few studies …
through which psychosocial stress impairs brain function. However, there are few studies …