User profiles for Helmut Heinsen

Helmut Heinsen

senior professor, Julius-Maximilians-Universit Würzbutg; FMUSP
Verified email at mail.uni-wuerzburg.de
Cited by 12425

Minicolumnar abnormalities in autism

…, AE Switala, H van Engeland, H Heinsen… - Acta …, 2006 - Springer
Autism is characterized by qualitative abnormalities in behavior and higher order cognitive
functions. Minicolumnar irregularities observed in autism provide a neurologically sound …

Molecular characterization of selectively vulnerable neurons in Alzheimer's disease

…, WW Seeley, S Spina, H Heinsen… - Nature …, 2021 - nature.com
Alzheimer’s disease (AD) is characterized by the selective vulnerability of specific neuronal
populations, the molecular signatures of which are largely unknown. To identify and …

The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies

…, J Mahlke, S Siswanto, R Krüger, H Heinsen… - Brain …, 2015 - Wiley Online Library
Parkinson's disease ( PD ) and dementia with L ewy bodies ( DLB ) are among the human
synucleinopathies, which show alpha‐synuclein immunoreactive neuronal and/or glial …

Neurons in the fusiform gyrus are fewer and smaller in autism

…, P von Cappeln, HWM Steinbusch, H Korr, H Heinsen… - Brain, 2008 - academic.oup.com
Abnormalities in face perception are a core feature of social disabilities in autism. Recent
functional magnetic resonance imaging studies showed that patients with autism could perform …

Locus coeruleus volume and cell population changes during Alzheimer's disease progression: a stereological study in human postmortem brains with potential …

…, W Jacob Filho, U Rueb, J Neuhaus, H Heinsen… - Alzheimer's & …, 2017 - Elsevier
Introduction Alzheimer's disease (AD) progression follows a specific spreading pattern,
emphasizing the need to characterize those brain areas that degenerate first. The brainstem's …

Atrophy of the cholinergic basal forebrain over the adult age range and in early stages of Alzheimer's disease

M Grothe, H Heinsen, SJ Teipel - Biological psychiatry, 2012 - Elsevier
BACKGROUND: The basal forebrain cholinergic system (BFCS) is known to undergo
moderate neurodegenerative changes during normal aging as well as severe atrophy in …

Measurement of basal forebrain atrophy in Alzheimer's disease using MRI

SJ Teipel, WH Flatz, H Heinsen, ALW Bokde… - Brain, 2005 - academic.oup.com
Alzheimer's disease is characterized by the degeneration and loss of cholinergic neurones
in the nucleus basalis Meynert, located within the substantia innominata at the ventral …

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

…, HR Siebner, M Mather, K Uludag, H Heinsen… - Brain, 2019 - academic.oup.com
Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

Volume, neuron density and total neuron number in five subcortical regions in schizophrenia

P Kreczmanski, H Heinsen, V Mantua, F Woltersdorf… - Brain, 2007 - academic.oup.com
Several studies have pointed to alterations in mean volumes, neuron densities and total neuron
numbers in the caudate nucleus (CN), putamen, nucleus accumbens (NA), mediodorsal …

Subregional basal forebrain atrophy in Alzheimer's disease: a multicenter study

I Kilimann, M Grothe, H Heinsen… - Journal of …, 2014 - content.iospress.com
Histopathological studies in Alzheimer's disease (AD) suggest severe and region-specific
neurodegeneration of the basal forebrain cholinergic system (BFCS). Here, we studied the …