User profiles for H. T. Kurata
kurata htUniversity of Alberta Verified email at ualberta.ca Cited by 2359 |
[HTML][HTML] A structural interpretation of voltage-gated potassium channel inactivation
After channel activation, and in some cases with sub-threshold depolarizing stimuli, Kv
channels undergo a time-dependent loss of conductivity by a family of mechanisms termed …
channels undergo a time-dependent loss of conductivity by a family of mechanisms termed …
[HTML][HTML] Inward rectifiers and their regulation by endogenous polyamines
VA Baronas, HT Kurata - Frontiers in physiology, 2014 - frontiersin.org
Inwardly-rectifying potassium (Kir) channels contribute to maintenance of the resting membrane
potential and regulation of electrical excitation in many cell types. Strongly rectifying Kir …
potential and regulation of electrical excitation in many cell types. Strongly rectifying Kir …
[HTML][HTML] Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells
Human embryonic stem cells (hESCs) were used as a model system of human pancreas
development to study characteristics of the polyhormonal cells that arise during fetal pancreas …
development to study characteristics of the polyhormonal cells that arise during fetal pancreas …
Differential Structure of Atrial and Ventricular KATP Atrial KATP Channels Require SUR1
The isoform-specific structure of the ATP-sensitive potassium (K ATP ) channel endows it with
differential fundamental properties, including physiological activation and pharmacology. …
differential fundamental properties, including physiological activation and pharmacology. …
Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2, and OCT3
Polyamines are ubiquitous organic cations implicated in many physiological processes.
Because they are positively charged at physiological pH, carrier-mediated systems are …
Because they are positively charged at physiological pH, carrier-mediated systems are …
[PDF][PDF] Secondary consequences of β cell inexcitability: Identification and prevention in a murine model of KATP-induced neonatal diabetes mellitus
ATP-insensitive K ATP channel mutations cause neonatal diabetes mellitus (NDM). To
explore the mechanistic etiology, we generated transgenic mice carrying an ATP-insensitive …
explore the mechanistic etiology, we generated transgenic mice carrying an ATP-insensitive …
[HTML][HTML] Atomic basis for therapeutic activation of neuronal potassium channels
Retigabine is a recently approved anticonvulsant that acts by potentiating neuronal M-current
generated by KCNQ2–5 channels, interacting with a conserved Trp residue in the channel …
generated by KCNQ2–5 channels, interacting with a conserved Trp residue in the channel …
The Polyamine Binding Site in Inward Rectifier K+ Channels
HT Kurata, LJ Marton, CG Nichols - The Journal of general physiology, 2006 - rupress.org
Strongly inwardly rectifying potassium channels exhibit potent and steeply voltage-dependent
block by intracellular polyamines. To locate the polyamine binding site, we have …
block by intracellular polyamines. To locate the polyamine binding site, we have …
Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels
… Kurata and Fedida, 2006), and therefore substitution of Tyr or Phe for Trp435 would be … Harley
T Kurata … Kurata HT, Fedida D. 2006. A structural interpretation of voltage-gated potassium …
T Kurata … Kurata HT, Fedida D. 2006. A structural interpretation of voltage-gated potassium …
Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations
LH Rodan, RC Spillmann, HT Kurata… - Genetics in …, 2021 - nature.com
Purpose CACNA1C encodes the alpha-1-subunit of a voltage-dependent L-type calcium
channel expressed in human heart and brain. Heterozygous variants in CACNA1C have …
channel expressed in human heart and brain. Heterozygous variants in CACNA1C have …