User profiles for H. T. Kurata

kurata ht

University of Alberta
Verified email at ualberta.ca
Cited by 2359

[HTML][HTML] A structural interpretation of voltage-gated potassium channel inactivation

HT Kurata, D Fedida - Progress in biophysics and molecular biology, 2006 - Elsevier
After channel activation, and in some cases with sub-threshold depolarizing stimuli, Kv
channels undergo a time-dependent loss of conductivity by a family of mechanisms termed …

[HTML][HTML] Inward rectifiers and their regulation by endogenous polyamines

VA Baronas, HT Kurata - Frontiers in physiology, 2014 - frontiersin.org
Inwardly-rectifying potassium (Kir) channels contribute to maintenance of the resting membrane
potential and regulation of electrical excitation in many cell types. Strongly rectifying Kir …

[HTML][HTML] Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells

…, S Erener, J Vela, X Hu, JD Johnson, HT Kurata… - Stem cell …, 2014 - Elsevier
Human embryonic stem cells (hESCs) were used as a model system of human pancreas
development to study characteristics of the polyhormonal cells that arise during fetal pancreas …

Differential Structure of Atrial and Ventricular KATP Atrial KATP Channels Require SUR1

TP Flagg, HT Kurata, R Masia, G Caputa… - Circulation …, 2008 - Am Heart Assoc
The isoform-specific structure of the ATP-sensitive potassium (K ATP ) channel endows it with
differential fundamental properties, including physiological activation and pharmacology. …

Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2, and OCT3

…, DC Li, GR Dake, HT Kurata… - Molecular …, 2013 - ACS Publications
Polyamines are ubiquitous organic cations implicated in many physiological processes.
Because they are positively charged at physiological pH, carrier-mediated systems are …

[PDF][PDF] Secondary consequences of β cell inexcitability: Identification and prevention in a murine model of KATP-induced neonatal diabetes mellitus

MS Remedi, HT Kurata, A Scott, FT Wunderlich… - Cell metabolism, 2009 - cell.com
ATP-insensitive K ATP channel mutations cause neonatal diabetes mellitus (NDM). To
explore the mechanistic etiology, we generated transgenic mice carrying an ATP-insensitive …

[HTML][HTML] Atomic basis for therapeutic activation of neuronal potassium channels

…, G Seebohm, CA Ahern, SA Pless, HT Kurata - Nature …, 2015 - nature.com
Retigabine is a recently approved anticonvulsant that acts by potentiating neuronal M-current
generated by KCNQ2–5 channels, interacting with a conserved Trp residue in the channel …

The Polyamine Binding Site in Inward Rectifier K+ Channels

HT Kurata, LJ Marton, CG Nichols - The Journal of general physiology, 2006 - rupress.org
Strongly inwardly rectifying potassium channels exhibit potent and steeply voltage-dependent
block by intracellular polyamines. To locate the polyamine binding site, we have …

Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels

SA Pless, JD Galpin, AP Niciforovic, HT Kurata… - Elife, 2013 - elifesciences.org
Kurata and Fedida, 2006), and therefore substitution of Tyr or Phe for Trp435 would be … Harley
T KurataKurata HT, Fedida D. 2006. A structural interpretation of voltage-gated potassium …

Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations

LH Rodan, RC Spillmann, HT Kurata… - Genetics in …, 2021 - nature.com
Purpose CACNA1C encodes the alpha-1-subunit of a voltage-dependent L-type calcium
channel expressed in human heart and brain. Heterozygous variants in CACNA1C have …