User profiles for Graham H. Diering

Graham H. Diering

Assistant professor Cell Biology and Physiology, University of North Carolina
Verified email at med.unc.edu
Cited by 2332

[PDF][PDF] The AMPA receptor code of synaptic plasticity

GH Diering, RL Huganir - Neuron, 2018 - cell.com
Changes in the properties and postsynaptic abundance of AMPA-type glutamate receptors (AMPARs)
are major mechanisms underlying various forms of synaptic plasticity, including …

Homer1a drives homeostatic scaling-down of excitatory synapses during sleep

GH Diering, RS Nirujogi, RH Roth, PF Worley… - Science, 2017 - science.org
Sleep is an essential process that supports learning and memory by acting on synapses
through poorly understood molecular mechanisms. Using biochemistry, proteomics, and …

[HTML][HTML] Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling

BD Fonseca, GH Diering, MA Bidinosti, K Dalal… - Journal of Biological …, 2012 - ASBMB
Mammalian target of rapamycin complex 1 (mTORC1) signaling is frequently dysregulated
in cancer. Inhibition of mTORC1 is thus regarded as a promising strategy in the treatment of …

[PDF][PDF] PKA-GluA1 coupling via AKAP5 controls AMPA receptor phosphorylation and cell-surface targeting during bidirectional homeostatic plasticity

GH Diering, AS Gustina, RL Huganir - Neuron, 2014 - cell.com
Bidirectional synaptic plasticity occurs locally at individual synapses during long-term potentiation
(LTP) or long-term depression (LTD), or globally during homeostatic scaling. LTP, LTD…

Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover

S Heo, GH Diering, CH Na… - Proceedings of the …, 2018 - National Acad Sciences
Memory formation is believed to result from changes in synapse strength and structure. While
memories may persist for the lifetime of an organism, the proteins and lipids that make up …

[HTML][HTML] Regulation of mTORC1 signaling by pH

AD Balgi, GH Diering, E Donohue, KKY Lam… - PloS one, 2011 - journals.plos.org
Background Acidification of the cytoplasm and the extracellular environment is associated
with many physiological and pathological conditions, such as intense exercise, hypoxia and …

Extensive phosphorylation of AMPA receptors in neurons

GH Diering, S Heo, NK Hussain… - Proceedings of the …, 2016 - National Acad Sciences
Regulation of AMPA receptor (AMPAR) function is a fundamental mechanism controlling
synaptic strength during long-term potentiation/depression and homeostatic scaling. AMPAR …

Sorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs

NK Hussain, GH Diering, J Sole… - Proceedings of the …, 2014 - National Acad Sciences
Activity-dependent changes in synaptic strength have long been postulated as cellular
correlates of learning and memory. Long-term potentiation (LTP), a well characterized form of …

[HTML][HTML] Endosomal pH in neuronal signaling and synaptic transmission: role of Na+/H+ exchanger NHE5

GH Diering, M Numata - Frontiers in physiology, 2014 - frontiersin.org
Neuronal precursor cells extend multiple neurites during development, one of which extends
to form an axon whereas others develop into dendrites. Chemical stimulation of N-methyl D-…

Regulation of dendritic spine growth through activity-dependent recruitment of the brain-enriched Na+/H+ exchanger NHE5

GH Diering, F Mills, SX Bamji… - Molecular biology of the …, 2011 - Am Soc Cell Biol
Subtle changes in cellular and extracellular pH within the physiological range have profound
impacts on synaptic activities. However, the molecular mechanisms underlying local pH …