User profiles for Gil Levkowitz
Gil LevkowitzWeizmann Institute of Science Verified email at weizmann.ac.il Cited by 9472 |
A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor
…, H Waterman, X Chen, GIL Levkowitz… - … and cellular biology, 1996 - Taylor & Francis
The ErbB family includes four homologous transmembrane tyrosine kinases. Whereas ErbB-1
binds to the epidermal growth factor (EGF), both ErbB-3 and ErbB-4 bind to the Neu …
binds to the epidermal growth factor (EGF), both ErbB-3 and ErbB-4 bind to the Neu …
[HTML][HTML] Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
G Levkowitz, H Waterman, SA Ettenberg, M Katz… - Molecular cell, 1999 - cell.com
Receptor desensitization is accomplished by accelerated endocytosis and degradation of
ligand–receptor complexes. An in vitro reconstituted system indicates that Cbl adaptor proteins …
ligand–receptor complexes. An in vitro reconstituted system indicates that Cbl adaptor proteins …
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
G Levkowitz, H Waterman, E Zamir, Z Kam… - Genes & …, 1998 - genesdev.cshlp.org
Ligand-induced down-regulation of two growth factor receptors, EGF receptor (ErbB-1) and
ErbB-3, correlates with differential ability to recruit c-Cbl, whose invertebrate orthologs are …
ErbB-3, correlates with differential ability to recruit c-Cbl, whose invertebrate orthologs are …
Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions.
…, L Soussan, H Waterman, G Levkowitz… - The EMBO …, 1996 - embopress.org
The ErbB family includes two receptors, ErbB‐1 and ErbB‐3, that respectively bind to epidermal
growth factor and Neu differentiation factor, and an orphan receptor, ErbB‐2. Unlike ErbB…
growth factor and Neu differentiation factor, and an orphan receptor, ErbB‐2. Unlike ErbB…
Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition
…, A Rojiani, A Rosenthal, G Levkowitz… - Journal of …, 2004 - Soc Neuroscience
The role of microglia in the removal of amyloid deposits after systemically administered anti-Aβ
antibodies remains unclear. In the current study, we injected Tg2576 APP transgenic …
antibodies remains unclear. In the current study, we injected Tg2576 APP transgenic …
[HTML][HTML] The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor
H Waterman, G Levkowitz, I Alroy, Y Yarden - Journal of Biological …, 1999 - ASBMB
Ligand-induced activation of surface receptors, including the epidermal growth factor
receptor (EGFR), is followed by a desensitization process involving endocytosis and receptor …
receptor (EGFR), is followed by a desensitization process involving endocytosis and receptor …
[HTML][HTML] ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms.
Neu differentiation factor (NDF or heregulin) elevates tyrosine phosphorylation of the ErbB-2
receptor tyrosine kinase, and it was, therefore, thought to function as a ligand of this receptor…
receptor tyrosine kinase, and it was, therefore, thought to function as a ligand of this receptor…
[HTML][HTML] Bivalence of EGF‐like ligands drives the ErbB signaling network
…, JD Moyer, LN Klapper, I Alroy, G Levkowitz… - The EMBO …, 1997 - embopress.org
Signaling by epidermal growth factor (EGF)‐like ligands is mediated by an interactive network
of four ErbB receptor tyrosine kinases, whose mechanism of ligand‐induced dimerization …
of four ErbB receptor tyrosine kinases, whose mechanism of ligand‐induced dimerization …
[HTML][HTML] Role of developmental factors in hypothalamic function
J Biran, M Tahor, E Wircer, G Levkowitz - Frontiers in neuroanatomy, 2015 - frontiersin.org
The hypothalamus is a brain region which regulates homeostasis by mediating endocrine,
autonomic and behavioral functions. It is comprised of several nuclei containing distinct …
autonomic and behavioral functions. It is comprised of several nuclei containing distinct …
[HTML][HTML] Alternative splicing of the pituitary adenylate cyclase-activating polypeptide receptor PAC1: mechanisms of fine tuning of brain activity
J Blechman, G Levkowitz - Frontiers in endocrinology, 2013 - frontiersin.org
Alternative splicing of the precursor mRNA encoding for the neuropeptide receptor PAC1/ADCYAP1R1
generates multiple protein products that exhibit pleiotropic activities. Recent …
generates multiple protein products that exhibit pleiotropic activities. Recent …