Mutations in pre-mRNA processing factors (PRPFs) cause autosomal-dominant retinitis
pigmentosa (RP), but it is unclear why mutations in ubiquitously expressed genes cause non-…

The availability of in vitro models of the human retina in which to perform pharmacological
and toxicological studies is an urgent and unmet need. An essential step for developing in …

We present a method for automated spike sorting for recordings with high-density, large-scale
multielectrode arrays. Exploiting the dense sampling of single neurons by multiple …

A<sc>bstract</sc> A major goal in the stem cell field is to generate tissues that can be utilized
as a universal tool for in vitro models of development and disease, drug development, or …

Tissue specific extracellular matrices (ECM) provide structural support and enable access to
molecular signals and metabolites, which are essential for directing stem cell renewal and …

Induced pluripotent stem cell (iPSC)-derived retinal organoids provide a platform to study
human retinogenesis, disease modeling, and compound screening. Although retinal organoids …

Retinal dystrophies often lead to blindness. Developing therapeutic interventions to restore
vision is therefore of paramount importance. Here we demonstrate the ability of pluripotent …

Retinal drug toxicity screening is essential for the development of safe treatment strategies
for a large number of diseases. To this end, retinal organoids derived from human pluripotent …

Microglia are the primary resident immune cells in the retina. They regulate neuronal survival
and synaptic pruning making them essential for normal development. Following injury, they …

How a population of retinal ganglion cells (RGCs) encodes the visual scene remains an open
question. Going beyond individual RGC coding strategies, results in salamander suggest …