The accumulation and extrusion of Ca 2+ in the pre- and postsynaptic compartments play a
critical role in initiating plastic changes in biological synapses. To emulate this fundamental …

Programmable RNA editing tools enable the reversible correction of mutant transcripts, reducing
the potential risk associated with permanent genetic changes associated with the use of …

Hair cell ribbon synapses exhibit several distinguishing features. Structurally, a dense body,
or ribbon, is anchored to the presynaptic membrane and tethers synaptic vesicles; …

EPSCs at the synapses of sensory receptors and of some CNS neurons include large events
thought to represent the synchronous release of the neurotransmitter contained in several …

Na + channel recovery from inactivation limits the maximal rate of neuronal firing. However,
the properties of presynaptic Na + channels are not well established because of the small …

An obligatory role for the calcium sensor synaptotagmins in stimulus-coupled release of
neurotransmitter is well established, but a role for synaptotagmin isoform involvement in …

The mammalian cochlea cannot regenerate functional hair cells (HCs) spontaneously. Atoh1
overexpression as well as other strategies are unable to generate functional HCs. Here, we …

CRISPR/RfxCas13d (CasRx) editing system can specifically and precisely cleave single-strand
RNAs, which is a promising treatment for various disorders by downregulation of related …

Gene therapy would benefit from the effective editing of targeted cells with CRISPR-Cas9
tools. However, it is difficult to precisely assess the editing performance in vivo because the …

Background The ideal neural interface or scaffold for stem cell therapy shall have good
biocompatibility promoting survival, maturation and integration of neural stem cells (NSCs) in …