Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

…, D Dickinson, AJ Hilliker, JP Phillips, GL Boulianne - Nature …, 1998 - nature.com
Reactive oxygen (RO) has been identified as an important effector in ageing and lifespan
determination 1, 2, 3. The specific cell types, however, in which oxidative damage acts to limit …

Production of functional chimaeric mouse/human antibody

GL Boulianne, N Hozumi, MJ Shulman - Nature, 1984 - nature.com
The availability of monoclonal antibodies has revived interest in immunotherapy. The ability
to influence an individual's immune state by administering immunoglobulin of the …

Green fluorescent protein as a vital marker and reporter of gene expression in Drosophila.

…, K Gustafson, GL Boulianne - Proceedings of the …, 1995 - National Acad Sciences
We have used the green fluorescent protein (GFP) from the jellyfish Aequorea victoria as a
vital marker/reporter in Drosophila melanogaster. Transgenic flies were generated in which …

[PDF][PDF] Neuralized functions as an E3 ubiquitin ligase during Drosophila development

…, C Commisso, L Zhou, CJ McGlade, GL Boulianne - Current biology, 2001 - cell.com
The Notch pathway is a widely studied means of intercellular signaling responsible for the
determination of cell fate, cell differentiation, and boundary formation (reviewed in [1, 2]). The …

[HTML][HTML] Neurexins and neuroligins: recent insights from invertebrates

D Knight, W Xie, GL Boulianne - Molecular neurobiology, 2011 - Springer
During brain development, each neuron must find and synapse with the correct pre- and
postsynaptic partners. The complexity of these connections and the relatively large distances …

Modeling Obesity and Its Associated Disorders in Drosophila

I Trinh, GL Boulianne - Physiology, 2013 - journals.physiology.org
In recent years, obesity has been recognized as a major public health problem due to its
increased prevalence in both children and adults and its association with numerous life-…

Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction

…, J Han, X Zeng, M Fang, GL Boulianne… - Journal of …, 2011 - Soc Neuroscience
… Correspondence should be addressed to either of the following: Gabrielle L. Boulianne
or Wei Xie, Toronto Medical Discovery Tower, 12th Floor, East Tower, 101 College Street, …

AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila

…, S Lallet, PA Leventis, GL Boulianne… - Molecular biology of …, 2011 - Am Soc Cell Biol
Regulated secretion of hormones, digestive enzymes, and other biologically active molecules
requires the formation of secretory granules. Clathrin and the clathrin adaptor protein …

big bang gene modulates gut immune tolerance in Drosophila

…, M Hoffmann, SY Kim, GL Boulianne… - Proceedings of the …, 2013 - National Acad Sciences
Chronic inflammation of the intestine is detrimental to mammals. Similarly, constant activation
of the immune response in the gut by the endogenous flora is suspected to be harmful to …

Subunit-destabilizing mutations in Drosophila copper/zinc superoxide dismutase: neuropathology and a model of dimer dysequilibrium.

…, JA Tainer, ED Getzoff, GL Boulianne… - Proceedings of the …, 1995 - National Acad Sciences
Mutations in Cu/Zn superoxide dismutase (SOD), a hallmark of familial amyotrophic lateral
sclerosis (FALS) in humans, are shown here to confer striking neuropathology in Drosophila. …