Apolipoprotein E ϵ4 and cerebral hemorrhage associated with amyloid angiopathy

SM Greenberg, G William Rebeck… - Annals of …, 1995 - Wiley Online Library
Cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular deposition of the
amyloid β‐peptide, leading to intracerebral hemorrhage in severe cases. Other than rare …

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

GW Rebeck, JS Reiter, DK Strickland, BT Hyman - Neuron, 1993 - cell.com
An increased prevalence of apolipoprotein E (ApoE)~ 4 allele exists in late onset familial
Alzheimer’s disease. We found, in sporadic Alzheimer’s disease, that 62% of patients …

Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy

…, HS Cho, JPG Vonsattel, GW Rebeck… - Annals of Neurology …, 2001 - Wiley Online Library
Several mutations in the amyloid precursor protein (APP) gene have been found to associate
with pathologic deposition of the β‐amyloid peptide (Aβ) in neuritic plaques or in the walls …

Lipoprotein receptor–mediated induction of matrix metalloproteinase by tissue plasminogen activator

X Wang, SR Lee, K Arai, SR Lee, K Tsuji, GW Rebeck… - Nature medicine, 2003 - nature.com
Although thrombolysis with tissue plasminogen activator (tPA) is a stroke therapy approved
by the US Food and Drug Administration, its efficacy may be limited by neurotoxic side effects …

[HTML][HTML] LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

MZ Kounnas, RD Moir, GW Rebeck, AI Bush… - Cell, 1995 - cell.com
The secreted form of β-amyloid precursor protein (APP) containing the Kunitz proteinase
inhibitor (KPI) domain, also called protease nexin II, is internalized and degraded by cells. We …

[HTML][HTML] Pathogenic effects of D23N Iowa mutant amyloid β-protein

…, HS Cho, SM Greenberg, GW Rebeck - Journal of Biological …, 2001 - ASBMB
Cerebral amyloid β-protein angiopathy (CAA) is a key pathological feature of patients with
Alzheimer's disease and certain related disorders. In these conditions the CAA is …

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model

…, Y Horikoshi-Sakuraba, M Mughal, GW Rebeck… - Brain research, 2008 - Elsevier
Epidemiological studies indicate that women have a higher risk of Alzheimer's disease (AD)
even after adjustment for age. Though transgenic mouse models of AD develop AD-related …

Clinical manifestations of cerebral amyloid angiopathy–related inflammation

JA Eng, MP Frosch, K Choi, GW Rebeck… - Annals of Neurology …, 2004 - Wiley Online Library
To explore the clinical effects of inflammation associated with vascular deposits of the
amyloid β peptide (Aβ), we analyzed 42 consecutive patients with pathologically diagnosed …

[HTML][HTML] APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease

…, S Estus, GW Rebeck, EJ Weeber, G Bu… - Journal of Biological …, 2012 - ASBMB
APOE4 is the greatest risk factor for Alzheimer disease (AD) and synergistic effects with
amyloid-β peptide (Aβ) suggest interactions among apoE isoforms and different forms of Aβ …

Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease

T Gomez‐Isla, HL West, GW Rebeck… - Annals of …, 1996 - Wiley Online Library
Inheritance of the apolipoprotein E (apoE) ε4 allele is associated with a high likelihood of
developing Alzheimer's disease (AD). The pathophysiologic basis of this genetic influence is …