Nervous system function and plasticity rely on the complex architecture of neuronal networks
elaborated during development, when neurons acquire their specific and complex shape. …

The adult blood system is established by hematopoietic stem cells (HSCs), which arise during
development from an endothelial-to-hematopoietic transition of cells comprising the floor …

Heparan sulfate proteoglycans (HSPGs) have long been implicated in a wide range of cell-cell
signaling and cell-matrix interactions, both in vitro and in vivo in invertebrate models. …

Spinal cord injury results in permanent sensorimotor loss in mammals, in part due to a lack
of injury-induced neurogenesis. The regeneration of neurons depends upon resident neural …

We studied three patients with severe skeletal dysplasia, T cell immunodeficiency, and
developmental delay. Whole-exome sequencing revealed homozygous missense mutations …

First discovered for their role in mediating programmed cell death and inflammatory responses,
caspases have now emerged as crucial regulators of other cellular and physiological …

Precise wiring of neural circuits is essential for brain connectivity and function. During
development, axons respond to diverse cues present in the extracellular matrix or at the surface of …

Proper arrangement of axonal projections into topographic maps is crucial for brain function,
especially in sensory systems. An important mechanism for map formation is pretarget axon …

The development of neural circuits is a complex process that relies on the proper navigation
of axons through their environment to their appropriate targets. While axon–environment …

Stathmin family phosphoproteins participate in the control of microtubule dynamics and have
been proposed to be involved in the control of neuronal differentiation. We examined the …