User profiles for Ewan St. John Smith

Ewan St. John Smith

Department of Pharmacology, University of Cambridge
Verified email at cam.ac.uk
Cited by 4558

[HTML][HTML] Nociceptors: a phylogenetic view

ESJ Smith, GR Lewin - Journal of Comparative Physiology A, 2009 - Springer
The ability to react to environmental change is crucial for the survival of an organism and an
essential prerequisite is the capacity to detect and respond to aversive stimuli. The …

[HTML][HTML] Advances in understanding nociception and neuropathic pain

E St. John Smith - Journal of neurology, 2018 - Springer
Pain results from the activation of a subset of sensory neurones termed nociceptors and has
evolved as a “detect and protect” mechanism. However, lesion or disease in the sensory …

The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole‐rat biology

…, DK Sarko, A Seluanov, A Shepard, M Smith… - Biological …, 2022 - Wiley Online Library
The naked mole‐rat (Heterocephalus glaber) has fascinated zoologists for at least half a
century. It has also generated considerable biomedical interest not only because of its …

Nerve growth factor and nociception: from experimental embryology to new analgesic therapy

GR Lewin, SG Lechner, ESJ Smith - Neurotrophic factors, 2014 - Springer
Nerve growth factor (NGF) is central to the development and functional regulation of
sensory neurons that signal the first events that lead to pain. These sensory neurons, called …

[HTML][HTML] Somatic mutation rates scale with lifespan across mammals

…, L Peachey, D Bochynska, ESJ Smith… - Nature, 2022 - nature.com
The rates and patterns of somatic mutation in normal tissues are largely unknown outside of
humans 1 , 2 , 3 , 4 , 5 , 6 – 7 . Comparative analyses can shed light on the diversity of …

Single-cell RNAseq reveals seven classes of colonic sensory neuron

…, WJ Winchester, DC Bulmer, G McMurray, ESJ Smith - Gut, 2019 - gut.bmj.com
Objective Integration of nutritional, microbial and inflammatory events along the gut-brain
axis can alter bowel physiology and organism behaviour. Colonic sensory neurons activate …

[PDF][PDF] The molecular and cellular identity of peripheral osmoreceptors

SG Lechner, S Markworth, K Poole, ESJ Smith… - Neuron, 2011 - cell.com
In mammals, the osmolality of the extracellular fluid (ECF) is highly stable despite radical
changes in salt/water intake and excretion. Afferent systems are required to detect hypo- or …

Mapping the neuroethological signatures of pain, analgesia, and recovery in mice

…, H Hilton, J Arnold, MA Tischfield, EA Yttri, ESJ Smith… - Neuron, 2023 - cell.com
Ongoing pain is driven by the activation and modulation of pain-sensing neurons, affecting
physiology, motor function, and motivation to engage in certain behaviors. The complexity of …

The molecular basis of acid insensitivity in the African naked mole-rat

ESJ Smith, D Omerbašić, SG Lechner, G Anirudhan… - Science, 2011 - science.org
Acid evokes pain by exciting nociceptors; the acid sensors are proton-gated ion channels that
depolarize neurons. The naked mole-rat (Heterocephalus glaber) is exceptional in its acid …

A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons

…, H Hu, X Yang, AJ Clark, E St. John Smith… - Science translational …, 2023 - science.org
Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes
associated with persistent pain. Chemogenetics has shown promise as a means to …