User profiles for Etienne Sibille

Etienne Sibille

CAMH & University of Toronto (Psychiatry & Pharmacology)
Verified email at camh.ca
Cited by 12808

Increased anxiety of mice lacking the serotonin1A receptor

CL Parks, PS Robinson, E Sibille… - Proceedings of the …, 1998 - National Acad Sciences
Brain serotonin (5-HT) has been implicated in a number of physiological processes and
pathological conditions. These effects are mediated by at least 14 different 5-HT receptors. We …

[HTML][HTML] Corticolimbic transcriptome changes are state-dependent and region-specific in a rodent model of depression and of antidepressant reversal

…, N Edgar, G Griebel, C Belzung, E Sibille - …, 2009 - nature.com
Gene microarrays may enable the elucidation of neurobiological changes underlying the
pathophysiology and treatment of major depression. However, previous studies of …

[HTML][HTML] Cross-laboratory analysis of brain cell type transcriptomes with applications to interpretation of bulk tissue data

…, L Toker, SJ Tripathy, B Li, B Rocco, E Sibille… - eneuro, 2017 - eneuro.org
Establishing the molecular diversity of cell types is crucial for the study of the nervous system.
We compiled a cross-laboratory database of mouse brain cell type-specific transcriptomes …

[HTML][HTML] Gene expression profiling of depression and suicide in human prefrontal cortex

E Sibille, V Arango, HC Galfalvy, P Pavlidis… - …, 2004 - nature.com
Mood disorders are a major cause of disability. Etiology includes genetic and environmental
factors, but the responsible genes have yet to be identified. Using DNA microarrays, we …

Cortical 5-HT2A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice

…, E Lambe, J González-Maeso, JP Hornung, E Sibille… - Science, 2006 - science.org
Serotonin [5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system
modulates depression and anxiety-related behaviors in humans and rodents, but the …

Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin1A receptors

Z Sarnyai, EL Sibille, C Pavlides… - Proceedings of the …, 2000 - National Acad Sciences
The hippocampus is a major limbic target of the brainstem serotonergic neurons that
modulate fear, anxiety, and learning through postsynaptic serotonin 1A receptors (5-HT 1A …

Chronic stress-induced behaviors correlate with exacerbated acute stress-induced cingulate cortex and ventral hippocampus activation

C Fee, T Prevot, K Misquitta, M Banasr, E Sibille - Neuroscience, 2020 - Elsevier
Altered activity of corticolimbic brain regions is a hallmark of stress-related illnesses, including
mood disorders, neurodegenerative diseases, and substance abuse disorders. Acute …

Molecular evidence for BDNF-and GABA-related dysfunctions in the amygdala of female subjects with major depression

…, K Martinowich, GC Tseng, DA Lewis, E Sibille - Molecular …, 2012 - nature.com
Women are twice as likely as men to develop major depressive disorder (MDD) and are
more prone to recurring episodes. Hence, we tested the hypothesis that the illness may …

Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function

…, G Gobbi, PC Debs, EL Sibille… - Proceedings of the …, 2001 - National Acad Sciences
Alterations in serotonin (5-hydroxytriptamine, 5-HT), norepinephrine, and γ-aminobutyric acid
have been linked to the pathophysiology of anxiety and depression, and medications that …

Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: relevance to emotionality and sex

JP Guilloux, M Seney, N Edgar, E Sibille - Journal of neuroscience …, 2011 - Elsevier
Defining anxiety- and depressive-like states in mice (emotionality) is best characterized by
the use of complementary tests, leading sometimes to puzzling discrepancies and lack of …