User profiles for Etienne Sibille
Etienne SibilleCAMH & University of Toronto (Psychiatry & Pharmacology) Verified email at camh.ca Cited by 12808 |
Increased anxiety of mice lacking the serotonin1A receptor
CL Parks, PS Robinson, E Sibille… - Proceedings of the …, 1998 - National Acad Sciences
Brain serotonin (5-HT) has been implicated in a number of physiological processes and
pathological conditions. These effects are mediated by at least 14 different 5-HT receptors. We …
pathological conditions. These effects are mediated by at least 14 different 5-HT receptors. We …
[HTML][HTML] Corticolimbic transcriptome changes are state-dependent and region-specific in a rodent model of depression and of antidepressant reversal
Gene microarrays may enable the elucidation of neurobiological changes underlying the
pathophysiology and treatment of major depression. However, previous studies of …
pathophysiology and treatment of major depression. However, previous studies of …
[HTML][HTML] Cross-laboratory analysis of brain cell type transcriptomes with applications to interpretation of bulk tissue data
Establishing the molecular diversity of cell types is crucial for the study of the nervous system.
We compiled a cross-laboratory database of mouse brain cell type-specific transcriptomes …
We compiled a cross-laboratory database of mouse brain cell type-specific transcriptomes …
[HTML][HTML] Gene expression profiling of depression and suicide in human prefrontal cortex
Mood disorders are a major cause of disability. Etiology includes genetic and environmental
factors, but the responsible genes have yet to be identified. Using DNA microarrays, we …
factors, but the responsible genes have yet to be identified. Using DNA microarrays, we …
Cortical 5-HT2A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice
Serotonin [5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system
modulates depression and anxiety-related behaviors in humans and rodents, but the …
modulates depression and anxiety-related behaviors in humans and rodents, but the …
Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin1A receptors
Z Sarnyai, EL Sibille, C Pavlides… - Proceedings of the …, 2000 - National Acad Sciences
The hippocampus is a major limbic target of the brainstem serotonergic neurons that
modulate fear, anxiety, and learning through postsynaptic serotonin 1A receptors (5-HT 1A …
modulate fear, anxiety, and learning through postsynaptic serotonin 1A receptors (5-HT 1A …
Chronic stress-induced behaviors correlate with exacerbated acute stress-induced cingulate cortex and ventral hippocampus activation
Altered activity of corticolimbic brain regions is a hallmark of stress-related illnesses, including
mood disorders, neurodegenerative diseases, and substance abuse disorders. Acute …
mood disorders, neurodegenerative diseases, and substance abuse disorders. Acute …
Molecular evidence for BDNF-and GABA-related dysfunctions in the amygdala of female subjects with major depression
Women are twice as likely as men to develop major depressive disorder (MDD) and are
more prone to recurring episodes. Hence, we tested the hypothesis that the illness may …
more prone to recurring episodes. Hence, we tested the hypothesis that the illness may …
Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function
…, G Gobbi, PC Debs, EL Sibille… - Proceedings of the …, 2001 - National Acad Sciences
Alterations in serotonin (5-hydroxytriptamine, 5-HT), norepinephrine, and γ-aminobutyric acid
have been linked to the pathophysiology of anxiety and depression, and medications that …
have been linked to the pathophysiology of anxiety and depression, and medications that …
Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: relevance to emotionality and sex
Defining anxiety- and depressive-like states in mice (emotionality) is best characterized by
the use of complementary tests, leading sometimes to puzzling discrepancies and lack of …
the use of complementary tests, leading sometimes to puzzling discrepancies and lack of …