Currently, the major drawback of gene therapy is the gene transfection rate. The two main
types of vectors that are used in gene therapy are based on viral or non-viral gene delivery …

Gene therapy using polymers such as chitosan shows good biocompatibility, but low
transfection efficiency. The mechanism of folic acid (FA) uptake by cells to promote targeting and …

Maintaining wakefulness is associated with a progressive increase in the need for sleep.
This phenomenon has been linked to changes in synaptic function. The synaptic adhesion …

Key points • Control of regional cardiac function, as mediated by the intrinsic cardiac (IC)
nervous system, is dependent upon its cardiac afferent neuronal inputs, changes in its central …

Key points The evoked cardiac response to bipolar cervical vagus nerve stimulation (VNS)
reflects a dynamic interaction between afferent mediated decreases in central …

The purpose of the study was to determine the effect of daily endurance treadmill training (2
h/day, 30 m/min) on motoneuron biophysical properties. Electrophysiological properties of …

This paper aims to determine whether chronic vagus nerve stimulation (VNS) mitigates
myocardial infarction (MI)-induced remodeling of the intrinsic cardiac nervous system (ICNS), …

No evidence currently exists that motoneurone adaptations in electrophysiological properties
can result from changes in the chronic level of neuromuscular activity. We examined, in …

Spinal cord transection influences the properties of motoneurons and muscles below the
lesion, but the effects of interventions that conserve muscle mass of the paralyzed limbs on …

Background: The ability to predict the long-term physical function and prognosis of hip
fracture patients during the early postoperative period is essential for surgeons and physical …