INTRODUCTION Alzheimer’s disease (AD) is the most common form of age-related dementia,
characterized by cognitive impairment, neurodegeneration, β-amyloid (Aβ) deposition, …

Stem cell technologies have facilitated the development of human cellular disease models
that can be used to study pathogenesis and test therapeutic candidates. These models hold …

Harmful materials in the blood are prevented from entering the healthy brain by a highly
selective blood–brain barrier (BBB), and impairment of barrier function has been associated with …

The relationship between amyloid-β (Aβ) species and tau pathology in Alzheimer’s disease (AD)
is not fully understood. Here, we provide direct evidence that Aβ42/40 ratio, not total Aβ …

Purpose With the recent rise of teleophthalmology due to coronavirus disease, health care
needs accurate and reliable methods of checking visual acuity remotely. The visual acuity as …

A central pathogenic event of Alzheimer's disease (AD) is the accumulation of the Aβ42
peptide, which is generated from amyloid-β precursor protein (APP) via cleavages by β- and γ-…

β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is required for the production of
β-amyloid (Aβ), one of the major pathogenic molecules of Alzheimer’s disease (AD), and is …

Adult hippocampal neurogenesis (AHN) is impaired prior to the onset of Alzheimer’s disease
(AD) pathology. We found that exercise provided cognitive benefit to 5× FAD mice, a mouse …

A three-dimensional (3D) cell culture system allows cells to grow and attach to their environments
in all three directions. As opposed to the conventional method of growing cells in a flat …

Cover illustration: Green fluorescent protein expressing human inducible pluripotent stem
cells (hiPSCs: green) genetically engineered to produce the herpes simplex virus thymidine …