User profiles for E. Darcq

Emmanuel Darcq

McGill/Douglas research centre
Verified email at douglas.mcgill.ca
Cited by 2440

Opioid receptors: drivers to addiction?

E Darcq, BL Kieffer - Nature Reviews Neuroscience, 2018 - nature.com
Drug addiction is a worldwide societal problem and public health burden, and results from
recreational drug use that develops into a complex brain disorder. The opioid system, one of …

Translating the habenula—from rodents to humans

LJ Boulos, E Darcq, BL Kieffer - Biological psychiatry, 2017 - Elsevier
The habenula (Hb) is a central structure connecting forebrain to midbrain regions. This
microstructure regulates monoaminergic systems, notably dopamine and serotonin, and …

The negative affect of protracted opioid abstinence: progress and perspectives from rodent models

L Welsch, J Bailly, E Darcq, BL Kieffer - Biological psychiatry, 2020 - Elsevier
Opioid use disorder (OUD) is characterized by the development of a negative emotional
state that develops after a history of long-term exposure to opioids. OUD represents a true …

[HTML][HTML] Chromatin remodeling—a novel strategy to control excessive alcohol drinking

V Warnault, E Darcq, A Levine, S Barak… - Translational psychiatry, 2013 - nature.com
Harmful excessive use of alcohol has a severe impact on society and it remains one of the
major causes of morbidity and mortality in the population. However, mechanisms that underlie …

Impaired emotional-like behavior and serotonergic function during protracted abstinence from chronic morphine

C Goeldner, PE Lutz, E Darcq, T Halter, D Clesse… - Biological …, 2011 - Elsevier
BACKGROUND:: Opiate abuse is a chronic relapsing disorder, and maintaining prolonged
abstinence remains a major challenge. Protracted abstinence is characterized by lowered …

MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption

E Darcq, V Warnault, K Phamluong, GM Besserer… - Molecular …, 2015 - nature.com
MicroRNAs (miRNAs) induce messenger RNA (mRNA) degradation and repress mRNA
translation. Several miRNAs control the expression of the brain-derived neurotrophic factor (…

Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula

Y Otsu, E Darcq, K Pietrajtis, F Mátyás, E Schwartz… - Science, 2019 - science.org
The unconventional N-methyl-d-aspartate (NMDA) receptor subunits GluN3A and GluN3B
can, when associated with the other glycine-binding subunit GluN1, generate excitatory …

Mu‐opioid receptor activation induces transcriptional plasticity in the central extended amygdala

K Befort, D Filliol, A Ghate, E Darcq… - European Journal of …, 2008 - Wiley Online Library
Addiction develops from the gradual adaptation of the brain to chronic drug exposure, and
involves genetic reprogramming of neuronal function. The central extended amygdala (EAc) …

Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome

…, M Reisert, S Ben Hamida, E Darcq… - Proceedings of the …, 2016 - National Acad Sciences
Connectome genetics seeks to uncover how genetic factors shape brain functional connectivity;
however, the causal impact of a single gene’s activity on whole-brain networks remains …

Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior

J Wang, SB Hamida, E Darcq, W Zhu… - Journal of …, 2012 - Soc Neuroscience
We found previously that acute ex vivo as well as repeated cycles of in vivo ethanol exposure
and withdrawal, including excessive voluntary consumption of ethanol, produces a long-…