User profiles for E. Darcq
Emmanuel DarcqMcGill/Douglas research centre Verified email at douglas.mcgill.ca Cited by 2440 |
Opioid receptors: drivers to addiction?
E Darcq, BL Kieffer - Nature Reviews Neuroscience, 2018 - nature.com
Drug addiction is a worldwide societal problem and public health burden, and results from
recreational drug use that develops into a complex brain disorder. The opioid system, one of …
recreational drug use that develops into a complex brain disorder. The opioid system, one of …
Translating the habenula—from rodents to humans
The habenula (Hb) is a central structure connecting forebrain to midbrain regions. This
microstructure regulates monoaminergic systems, notably dopamine and serotonin, and …
microstructure regulates monoaminergic systems, notably dopamine and serotonin, and …
The negative affect of protracted opioid abstinence: progress and perspectives from rodent models
L Welsch, J Bailly, E Darcq, BL Kieffer - Biological psychiatry, 2020 - Elsevier
Opioid use disorder (OUD) is characterized by the development of a negative emotional
state that develops after a history of long-term exposure to opioids. OUD represents a true …
state that develops after a history of long-term exposure to opioids. OUD represents a true …
[HTML][HTML] Chromatin remodeling—a novel strategy to control excessive alcohol drinking
Harmful excessive use of alcohol has a severe impact on society and it remains one of the
major causes of morbidity and mortality in the population. However, mechanisms that underlie …
major causes of morbidity and mortality in the population. However, mechanisms that underlie …
Impaired emotional-like behavior and serotonergic function during protracted abstinence from chronic morphine
BACKGROUND:: Opiate abuse is a chronic relapsing disorder, and maintaining prolonged
abstinence remains a major challenge. Protracted abstinence is characterized by lowered …
abstinence remains a major challenge. Protracted abstinence is characterized by lowered …
MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption
E Darcq, V Warnault, K Phamluong, GM Besserer… - Molecular …, 2015 - nature.com
MicroRNAs (miRNAs) induce messenger RNA (mRNA) degradation and repress mRNA
translation. Several miRNAs control the expression of the brain-derived neurotrophic factor (…
translation. Several miRNAs control the expression of the brain-derived neurotrophic factor (…
Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula
The unconventional N-methyl-d-aspartate (NMDA) receptor subunits GluN3A and GluN3B
can, when associated with the other glycine-binding subunit GluN1, generate excitatory …
can, when associated with the other glycine-binding subunit GluN1, generate excitatory …
Mu‐opioid receptor activation induces transcriptional plasticity in the central extended amygdala
K Befort, D Filliol, A Ghate, E Darcq… - European Journal of …, 2008 - Wiley Online Library
Addiction develops from the gradual adaptation of the brain to chronic drug exposure, and
involves genetic reprogramming of neuronal function. The central extended amygdala (EAc) …
involves genetic reprogramming of neuronal function. The central extended amygdala (EAc) …
Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome
Connectome genetics seeks to uncover how genetic factors shape brain functional connectivity;
however, the causal impact of a single gene’s activity on whole-brain networks remains …
however, the causal impact of a single gene’s activity on whole-brain networks remains …
Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior
We found previously that acute ex vivo as well as repeated cycles of in vivo ethanol exposure
and withdrawal, including excessive voluntary consumption of ethanol, produces a long-…
and withdrawal, including excessive voluntary consumption of ethanol, produces a long-…