Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors

JE Anttila, KW Whitaker, ES Wires, BK Harvey… - Progress in Neuro …, 2017 - Elsevier
Stroke is the leading cause of disability in adults. Drug treatments that target stroke-induced
pathological mechanisms and promote recovery are desperately needed. In the brain, an …

[HTML][HTML] Preclinical model systems of ryanodine receptor 1-related myopathies and malignant hyperthermia: a comprehensive scoping review of works published 1990 …

TA Lawal, ES Wires, NL Terry, JJ Dowling… - Orphanet journal of rare …, 2020 - Springer
Background Pathogenic variations in the gene encoding the skeletal muscle ryanodine
receptor (RyR1) are associated with malignant hyperthermia (MH) susceptibility, a life-…

[HTML][HTML] The function of KDEL receptors as UPR genes in disease

ES Wires, KA Trychta, LM Kennedy… - International journal of …, 2021 - mdpi.com
The KDEL receptor retrieval pathway is essential for maintaining resident proteins in the
endoplasmic reticulum (ER) lumen. ER resident proteins serve a variety of functions, including …

SERCaMP: a carboxy-terminal protein modification that enables monitoring of ER calcium homeostasis

MJ Henderson, ES Wires, KA Trychta… - Molecular biology of …, 2014 - Am Soc Cell Biol
Endoplasmic reticulum (ER) calcium homeostasis is disrupted in diverse pathologies, including
neurodegeneration, cardiovascular diseases, and diabetes. Temporally defining calcium …

High fat diet disrupts endoplasmic reticulum calcium homeostasis in the rat liver

ES Wires, KA Trychta, S Bäck, A Sulima, KC Rice… - Journal of …, 2017 - Elsevier
Background & Aims Disruption to endoplasmic reticulum (ER) calcium homeostasis has been
implicated in obesity, however, the ability to longitudinally monitor ER calcium fluctuations …

Methamphetamine activates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and induces human immunodeficiency virus (HIV) transcription in …

ES Wires, D Alvarez, C Dobrowolski, Y Wang… - Journal of …, 2012 - Springer
Human immunodeficiency virus (HIV) primarily infects glial cells in the central nervous system
(CNS). Recent evidence suggests that HIV-infected individuals who abuse drugs such as …

[PDF][PDF] A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome

…, KA Trychta, SM Yang, S Bäck, A Yasgar, ES Wires… - Cell reports, 2021 - cell.com
Endoplasmic reticulum (ER) dysregulation is associated with pathologies including
neurodegenerative, muscular, and diabetic conditions. Depletion of ER calcium can lead to the loss …

Post-stroke intranasal (+)-naloxone delivery reduces microglial activation and improves behavioral recovery from ischemic injury

JE Anttila, K Albert, ES Wires, K Mätlik, LC Loram… - Eneuro, 2018 - eneuro.org
Ischemic stroke is the leading cause of disability, and effective therapeutic strategies are
needed to promote complete recovery. Neuroinflammation plays a significant role in stroke …

[HTML][HTML] Longitudinal monitoring of Gaussia and Nano luciferase activities to concurrently assess ER calcium homeostasis and ER stress in vivo

ES Wires, MJ Henderson, X Yan, S Bäck, KA Trychta… - PLoS …, 2017 - journals.plos.org
The endoplasmic reticulum (ER) is essential to many cellular processes including protein
processing, lipid metabolism and calcium storage. The ability to longitudinally monitor ER …

Monitoring endoplasmic reticulum calcium homeostasis using a Gaussia luciferase SERCaMP

MJ Henderson, ES Wires, KA Trychta, X Yan… - JoVE (Journal of …, 2015 - jove.com
The endoplasmic reticulum (ER) contains the highest level of intracellular calcium, with
concentrations approximately 5,000-fold greater than cytoplasmic levels. Tight control over ER …