Backgroud Variations in the expression of the Netrin-1 guidance cue receptor DCC (deleted
in colorectal cancer) appear to confer resilience or susceptibility to psychopathologies …

Low miR-218 expression in the medial prefrontal cortex (mPFC) is a consistent trait of
depression. Here we assessed whether miR-218 in the mPFC confers resilience or susceptibility …

Initiating drug use during adolescence increases the risk of developing addiction or other
psychopathologies later in life, with long-term outcomes varying according to sex and exact …

Epidemiological studies implicate prenatal infection as a risk factor for the development of
schizophrenia and autism. Subjects with schizophrenia and autism are reported to exhibit …

A novel member of the ionotropic ATP receptor gene family has been identified in human
brain. This 422 amino acid long P2X receptor subunit has 62% sequence identity with rat P2X …

Gabapentin (Neurontin, Pfizer Global R & D) is a novel anticonvulsant, antihyperalgesic, and
antinociceptive agent with a poorly understood mechanism of action. In this study, we show …

The binding and internalization of radioiodinated and fluorescent μ and Δ opioid peptides in
mammalian cells were quantitatively studied by biochemical techniques and directly …

A growing body of evidence suggests that neuropeptide binding to G protein-linked
receptors may result in internalization of receptor-ligand complexes, followed by intracellular …

The neuropeptide neurotensin (NT) is known to be internalized in a receptor-mediated
fashion into its target cells. To gain insight into the mechanisms underlying this process, we …

For some individuals, social stress is a risk factor for psychiatric disorders characterized by
adolescent onset, prefrontal cortex (PFC) dysfunction and cognitive impairments. Social …