User profiles for Ditte Dencker

Ditte Dencker Thorbek

Post Doc, Neuropsykiatrisk Laboratorium
Verified email at regionh.dk
Cited by 1149

A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors

J Jeon, D Dencker, G Wörtwein… - Journal of …, 2010 - Soc Neuroscience
Acetylcholine (ACh) regulates many key functions of the CNS by activating cell surface
receptors referred to as muscarinic ACh receptors (M 1 –M 5 mAChRs). Like other mAChR …

Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents

M Bubser, TM Bridges, D Dencker… - ACS chemical …, 2014 - ACS Publications
Positive allosteric modulators (PAMs) of the M 4 muscarinic acetylcholine receptor (mAChR)
represent a novel approach for the treatment of psychotic symptoms associated with …

Major femoral vascular access complications after coronary diagnostic and interventional procedures: a Danish register study

D Dencker, F Pedersen, T Engstrøm, L Køber… - International Journal of …, 2016 - Elsevier
Background Vascular access complications after coronary angiography (CAG) and percutaneous
coronary intervention (PCI) are known to increase morbidity, prolong hospitalization …

Muscarinic acetylcholine receptor subtypes as potential drug targets for the treatment of schizophrenia, drug abuse, and Parkinson's disease

D Dencker, M Thomsen, G Wörtwein… - ACS chemical …, 2012 - ACS Publications
The neurotransmitter dopamine plays important roles in modulating cognitive, affective, and
motor functions. Dysregulation of dopaminergic neurotransmission is thought to be involved …

The glucagon-like peptide 1 receptor agonist Exendin-4 decreases relapse-like drinking in socially housed mice

M Thomsen, D Dencker, G Wörtwein, P Weikop… - Pharmacology …, 2017 - Elsevier
Glucagon-like peptide-1 (GLP-1) is a gut peptide that regulates food intake and glucose
metabolism. GLP-1 is also produced and released in the brain, and GLP-1 receptors are …

Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice

LS Schmidt, M Thomsen, P Weikop, D Dencker… - …, 2011 - Springer
Rationale The reinforcing effects of cocaine are mediated by the mesolimbic dopamine system.
Behavioral and neurochemical studies have shown that the cholinergic muscarinic M 4 …

Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice

RW Gould, D Dencker, M Grannan… - ACS chemical …, 2015 - ACS Publications
The M 1 muscarinic acetylcholine receptor (mAChR) subtype has been implicated in the
underlying mechanisms of learning and memory and represents an important potential …

Antipsychotic-induced catalepsy is attenuated in mice lacking the M4 muscarinic acetylcholine receptor

A Fink-Jensen, LS Schmidt, D Dencker… - European journal of …, 2011 - Elsevier
A delicate balance exists between the central dopaminergic and cholinergic neurotransmitter
systems with respect to motor function. An imbalance can result in motor dysfunction as …

Physiological roles of CNS muscarinic receptors gained from knockout mice

M Thomsen, G Sørensen, D Dencker - Neuropharmacology, 2018 - Elsevier
Because the five muscarinic acetylcholine receptor subtypes have overlapping distributions
in many CNS tissues, and because ligands with a high degree of selectivity for a given …

Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist …

D Dencker, G Wörtwein, P Weikop, J Jeon… - Journal of …, 2011 - Soc Neuroscience
Disturbances in central dopaminergic neurotransmission are believed to be centrally involved
in the pathogenesis of schizophrenia. Central dopaminergic and cholinergic systems …