Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease
High frequency deep brain stimulation is an effective therapy for motor symptoms in Parkinson's
disease. However, the relative clinical efficacy of regular versus non-regular temporal …
disease. However, the relative clinical efficacy of regular versus non-regular temporal …
Principles of electrical stimulation of neural tissue
DT Brocker, WM Grill - Handbook of clinical neurology, 2013 - Elsevier
Deep brain stimulation is a remarkable therapy that has mainstreamed electrical stimulation
of the brain for the treatment of neurological dysfunction. To appreciate the mechanisms of …
of the brain for the treatment of neurological dysfunction. To appreciate the mechanisms of …
Optimized temporal pattern of brain stimulation designed by computational evolution
Brain stimulation is a promising therapy for several neurological disorders, including
Parkinson’s disease. Stimulation parameters are selected empirically and are limited to the …
Parkinson’s disease. Stimulation parameters are selected empirically and are limited to the …
A biophysical model of the cortex-basal ganglia-thalamus network in the 6-OHDA lesioned rat model of Parkinson's disease
K Kumaravelu, DT Brocker, WM Grill - Journal of computational …, 2016 - Springer
Electrical stimulation of sub-cortical brain regions (the basal ganglia), known as deep brain
stimulation (DBS), is an effective treatment for Parkinson’s disease (PD). Chronic high …
stimulation (DBS), is an effective treatment for Parkinson’s disease (PD). Chronic high …
[HTML][HTML] Evoked potentials reveal neural circuits engaged by human deep brain stimulation
Background Deep brain stimulation (DBS) is an effective therapy for reducing the motor
symptoms of Parkinson’s disease, but the mechanisms of action of DBS and neural correlates of …
symptoms of Parkinson’s disease, but the mechanisms of action of DBS and neural correlates of …
Measurement of evoked potentials during thalamic deep brain stimulation
Background Deep brain stimulation (DBS) treats the symptoms of several movement
disorders, but optimal selection of stimulation parameters remains a challenge. The evoked …
disorders, but optimal selection of stimulation parameters remains a challenge. The evoked …
Short pauses in thalamic deep brain stimulation promote tremor and neuronal bursting
Objective We conducted intraoperative measurements of tremor during DBS containing short
pauses (⩽50 ms) to determine if there is a minimum pause duration that preserves tremor …
pauses (⩽50 ms) to determine if there is a minimum pause duration that preserves tremor …
Beta frequency oscillations in the subthalamic nucleus are not sufficient for the development of symptoms of parkinsonian bradykinesia/akinesia in rats
Substantial correlative evidence links the synchronized, oscillatory patterns of neural activity
that emerge in Parkinson’s disease (PD) in the beta (β) frequency range (13–30 Hz) with …
that emerge in Parkinson’s disease (PD) in the beta (β) frequency range (13–30 Hz) with …
Patterned low-frequency deep brain stimulation induces motor deficits and modulates cortex-basal ganglia neural activity in healthy rats
CS Oza, DT Brocker, CE Behrend… - Journal of …, 2018 - journals.physiology.org
Deep brain stimulation (DBS) is an effective therapy for movement disorders, including
Parkinson’s disease (PD), although the mechanisms of action remain unclear. Abnormal …
Parkinson’s disease (PD), although the mechanisms of action remain unclear. Abnormal …
Effects of ramped-frequency thalamic deep brain stimulation on tremor and activity of modeled neurons
Objective We conducted intraoperative measurements of tremor to quantify the effects of
temporally patterned ramped-frequency DBS trains on tremor. Methods Seven patterns of …
temporally patterned ramped-frequency DBS trains on tremor. Methods Seven patterns of …