User profiles for David E. Moorman
David MoormanUniversity of Massachusetts Amherst Verified email at umass.edu Cited by 3871 |
Lateral hypothalamic orexin/hypocretin neurons: a role in reward-seeking and addiction
Orexins (synonymous with hypocretins) are recently discovered neuropeptides made exclusively
in hypothalamus. Behavioral, anatomical, and neurophysiological studies show that a …
in hypothalamus. Behavioral, anatomical, and neurophysiological studies show that a …
Role of lateral hypothalamic orexin neurons in reward processing and addiction
Orexins (also known as hypocretins) are recently discovered neuropeptides made
exclusively in hypothalamic neurons that have been shown to be important in narcolepsy/cataplexy …
exclusively in hypothalamic neurons that have been shown to be important in narcolepsy/cataplexy …
Motivational activation: a unifying hypothesis of orexin/hypocretin function
Orexins (hypocretins) are two peptides (orexin A and B) produced from the pre-pro-orexin
precursor and expressed in a limited region of dorsolateral hypothalamus. Orexins were …
precursor and expressed in a limited region of dorsolateral hypothalamus. Orexins were …
Differential roles of medial prefrontal subregions in the regulation of drug seeking
DE Moorman, MH James, EM McGlinchey… - Brain research, 2015 - Elsevier
The prefrontal cortex plays an important role in shaping cognition and behavior. Many studies
have shown that medial prefrontal cortex (mPFC) plays a key role in seeking, extinction, …
have shown that medial prefrontal cortex (mPFC) plays a key role in seeking, extinction, …
Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity
Orexins (also named hypocretins) are recently discovered neuropeptides made exclusively
in the hypothalamus. Recent studies have shown that orexin cells located specifically in …
in the hypothalamus. Recent studies have shown that orexin cells located specifically in …
Multiple roles for orexin/hypocretin in addiction
Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …
Phasic locus coeruleus activity regulates cortical encoding of salience information
EM Vazey, DE Moorman… - Proceedings of the …, 2018 - National Acad Sciences
Phasic activation of locus coeruleus (LC)-norepinephrine (NE) neurons is associated with
focused attention and behavioral responses to salient stimuli. We used cell-type–specific …
focused attention and behavioral responses to salient stimuli. We used cell-type–specific …
[BOOK][B] A decade of orexin/hypocretin and addiction: where are we now?
One decade ago, our laboratory provided the first direct evidence linking orexin/hypocretin
signaling with drug seeking by showing that activation of these neurons promotes …
signaling with drug seeking by showing that activation of these neurons promotes …
Prefrontal neurons encode context-based response execution and inhibition in reward seeking and extinction
DE Moorman, G Aston-Jones - Proceedings of the National …, 2015 - National Acad Sciences
The prefrontal cortex (PFC) guides execution and inhibition of behavior based on contextual
demands. In rodents, the dorsal/prelimbic (PL) medial PFC (mPFC) is frequently considered …
demands. In rodents, the dorsal/prelimbic (PL) medial PFC (mPFC) is frequently considered …
Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models
Over the past 20 years there has been a growing interest in the neural underpinnings of cost/benefit
decision-making. Recent studies with animal models have made considerable …
decision-making. Recent studies with animal models have made considerable …