Orexins (synonymous with hypocretins) are recently discovered neuropeptides made exclusively
in hypothalamus. Behavioral, anatomical, and neurophysiological studies show that a …

Orexins (also known as hypocretins) are recently discovered neuropeptides made
exclusively in hypothalamic neurons that have been shown to be important in narcolepsy/cataplexy …

Orexins (hypocretins) are two peptides (orexin A and B) produced from the pre-pro-orexin
precursor and expressed in a limited region of dorsolateral hypothalamus. Orexins were …

The prefrontal cortex plays an important role in shaping cognition and behavior. Many studies
have shown that medial prefrontal cortex (mPFC) plays a key role in seeking, extinction, …

Orexins (also named hypocretins) are recently discovered neuropeptides made exclusively
in the hypothalamus. Recent studies have shown that orexin cells located specifically in …

Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …

Phasic activation of locus coeruleus (LC)-norepinephrine (NE) neurons is associated with
focused attention and behavioral responses to salient stimuli. We used cell-type–specific …

One decade ago, our laboratory provided the first direct evidence linking orexin/hypocretin
signaling with drug seeking by showing that activation of these neurons promotes …

The prefrontal cortex (PFC) guides execution and inhibition of behavior based on contextual
demands. In rodents, the dorsal/prelimbic (PL) medial PFC (mPFC) is frequently considered …

Over the past 20 years there has been a growing interest in the neural underpinnings of cost/benefit
decision-making. Recent studies with animal models have made considerable …