Estrogen receptor (ER)-negative tumors represent 20–30% of all breast cancers, with a higher
proportion occurring in younger women and women of African ancestry 1 . The etiology 2 …

Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African
ancestry compared to women of European ancestry. In search of common risk alleles for …

Methylation of cytosines at CpG sites is a common epigenetic DNA modification that can be
measured by a large number of methods, now even in a genome-wide manner for hundreds …

Background In 2011, WHO member states signed up to the 25 × 25 initiative, a plan to cut
mortality due to non-communicable diseases by 25% by 2025. However, socioeconomic …

Despite the high prevalence of nonalcoholic fatty liver disease (NAFLD), little is known of its
pathogenesis based on study of human liver samples. By the use of Affymetrix GeneChips (…

Existing computational methods for drug repositioning either rely only on the gene expression
response of cell lines after treatment, or on drug-to-disease relationships, merging several …

De novo drug design is a computational approach that generates novel molecular structures
from atomic building blocks with no a priori relationships. Conventional methods include …

Despite recent advances in understanding microbial diversity in skin homeostasis, the relevance
of microbial dysbiosis in inflammatory disease is poorly understood. Here we perform a …

The mechanisms of inflammation in acne are currently subject of intense investigation. This
study focused on the activation of adaptive and innate immunity in clinically early visible …

Genome-wide association studies (GWAS) of breast cancer defined by hormone receptor
status have revealed loci contributing to susceptibility of estrogen receptor (ER)-negative …