The endogenous opioid system (EOS) plays a critical role in addictive processes. Molecular
dysregulations in this system may be specific for different stages of addiction cycle and …

DNA methylation, which is modulated by both genetic factors and environmental exposures,
may offer a unique opportunity to discover novel biomarkers of disease-related brain …

Brain injuries can interrupt descending neural pathways that convey motor commands from
the cortex to spinal motoneurons. Here, we demonstrate that a unilateral injury of the …

Traumatic brain injury (TBI) is an established risk factor for neurodegenerative disorders and
dementias. Epigenetic modifications, such as DNA methylation, may alter the expression of …

Alcohol misuse is a major public health problem originating from genetic and environmental
risk factors. Alterations in the brain epigenome may orchestrate changes in gene expression …

Molecular changes induced by excessive alcohol consumption may underlie formation of
dysphoric state during acute and protracted alcohol withdrawal which leads to craving and …

Background The COVID-19 pandemic, which has a prominent social and economic impact
worldwide, shows a largely unexplained male bias for the severity and mortality of the disease…

Regulation of the formation and rewiring of neural circuits by neuropeptides may require
coordinated production of these signaling molecules and their receptors that may be …

Unilateral traumatic brain injury and stroke result in asymmetric postural and motor deficits
including contralateral hemiplegia and hemiparesis. In animals, a localized unilateral brain …

Mechanisms of motor deficits (eg hemiparesis and hemiplegia) secondary to stroke and
traumatic brain injury remain poorly understood. In early animal studies, a unilateral lesion to the …