Perineuronal nets (PNNs), a specialized form of extracellular matrix, are abnormal in the brains
of people with Rett syndrome (RTT). We previously reported that PNNs function to restrict …

Mineralocorticoid receptors (MRs) in the brain play a role in learning and memory, neuronal
differentiation, and regulation of the stress response. Within the hippocampus, the highest …

The noradrenergic locus coeruleus (LC) is among the earliest sites of tau and α-synuclein
pathology in Alzheimer’s disease (AD) and Parkinson’s disease (PD), respectively. The onset …

Pyramidal neurons in hippocampal area CA2 are distinct from neighboring CA1 in that they
resist synaptic long-term potentiation (LTP) at CA3 Schaffer collateral synapses. Regulator of …

Pyramidal cells in hippocampal area CA2 have synaptic properties that are distinct from the
other CA subregions. Notably, this includes a lack of typical long‐term potentiation of stratum …

Regulator of G Protein Signaling 14 (RGS14) is a complex scaffolding protein that integrates
G protein and MAPK signaling pathways. In the adult mouse brain, RGS14 is predominantly …

Exposure to unfamiliar odorants induces an array of repetitive defensive and non-defensive
behaviors in rodents which likely reflect adaptive stress responses to the uncertain valence …

The human genome contains vast genetic diversity as naturally occurring coding variants,
yet the impact of these variants on protein function and physiology is poorly understood. …

Rationale In rodents, exposure to novel environments or psychostimulants promotes
locomotion. Indeed, locomotor reactivity to novelty strongly predicts behavioral responses to …

In rodents, exposure to predator odors such as cat urine acts as a severe stressor that
engages innate defensive behaviors critical for survival in the wild. The neurotransmitters …