… D 1 receptor-expressing neurons, we generated mice that lack M 4 receptors only in D 1
receptor-expressing cells (D … xanomeline were also almost completely abolished in D 1 -M 4 –/– …

… Selective deletion of M 4 receptors in dopamine D 1 receptor-expressing neurons (D 1 -M
4 −/− mice) confirmed that striatal M 4 receptors are predominantly expressed in D 1 -…

… To create mutant mice that lack M 4 mAChRs only in D 1 receptor-expressing neurons, we
used Cre/loxP and Flp/frt technology. We first generated a targeting vector that was based on …

… VU0467154 (B) and VU0152100 (D) cause a progressive leftward shift of an ACh
concentration–response curve at rat M 4 . Data are shown as means ± SEM of at least three …

Background Vascular access complications after coronary angiography (CAG) and percutaneous
coronary intervention (PCI) are known to increase morbidity, prolong hospitalization …

… 2d). Scrutiny of the individual data revealed that 5 of 6 mice in the saline group drank alcohol
before water after re-introduction of the alcohol solution, while only 1 of 9 Exendin-4 treated …

… (C) Percent accuracy and (D) survival plots across 12 consecutive days in wild-type (black)
and M 1 KO (gray) mice treated with vehicle or BQCA when exposed to 60 trials per session. (…

… and by the selective dopamine D 1 receptor agonist SKF … D 1 or D 2 receptor expression,
we performed the SHIRPA behavioral phenotype assessment as well as dopamine D 1 and D …

… to changes in dopamine D 1 or D 2 receptor expression in the caudate-putamen and
nucleus accumbens since no significant change in dopamine D 1 and D 2 receptor density was …

… D 1 dopamine receptors seems to be especially important in modulating dopamine-dependent
behaviors. Using mutant mice that lack the M 4 mAChR only in D 1 … colocalized with D 1 …