User profiles for D. F. Marker

Daniel Marker

Assistant Professor of Neuropathology
Verified email at upmc.edu
Cited by 906

Methodologies for surveying herpetofauna mortality on rural highways

…, EK Crowe, C Mangan, DF Marker… - The Journal of …, 2007 - Wiley Online Library
Road mortality can contribute to local and regional declines in amphibian and reptile populations.
Thus, there is a need to accurately and efficiently identify hotspots of road‐mortality for …

[HTML][HTML] Human papillomavirus type 16 E6 and E 7 proteins alter NF-kB in cultured cervical epithelial cells and inhibition of NF-kB promotes cell growth and …

ER Vandermark, KA Deluca, CR Gardner, DF Marker… - Virology, 2012 - Elsevier
The NF-kB family of transcription factors regulates important biological functions including cell
growth, survival and the immune response. We found that Human Papillomavirus type 16 (…

[HTML][HTML] LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein

DF Marker, JM Puccini, TE Mockus, J Barbieri… - Journal of …, 2012 - Springer
… When we examined these cells using ICC, we found the presence of some inclusions
that stained positive for neuronal markers, but these inclusions were much smaller and …

Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3

…, S Pollack, O Polesskaya, DF Marker… - Journal of medicinal …, 2013 - ACS Publications
Inhibition of mixed lineage kinase 3 (MLK3) is a potential strategy for treatment of Parkinson’s
disease and HIV-1 associated neurocognitive disorders (HAND), requiring an inhibitor that …

The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated …

DF Marker, MÈ Tremblay, JM Puccini… - Journal of …, 2013 - Soc Neuroscience
… We stained for the neutrophil marker 7/4 (white), GFP (green), which was present only in
monocytes derived from the peripheral bone marrow, and the monocyte/microglia marker Iba-1 (…

Germ cell tumors of the central nervous system: a brief review and site-specific considerations

DF Marker, TM Pearce - Seminars in Diagnostic Pathology, 2023 - Elsevier
… Diagnosis should involve review of the clinical history, imaging studies, and assessment
of serum and cerebrospinal fluid tumor markers. Current therapeutic strategies involving …

A thin-skull window technique for chronic two-photon in vivo imaging of murine microglia in models of neuroinflammation

DF Marker, ME Tremblay, SM Lu, AK Majewska… - JoVE (Journal of …, 2010 - jove.com
Traditionally in neuroscience, in vivo two photon imaging of the murine central nervous
system has either involved the use of open-skull1,2 or thinned-skull 3 preparations. While the …

Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders

JM Puccini, DF Marker, T Fitzgerald… - Journal of …, 2015 - Soc Neuroscience
Leucine-rich repeat kinase 2 (LRRK2) is the single most common genetic cause of both
familial and sporadic Parkinson's disease (PD), both of which share pathogenetic and …

[HTML][HTML] HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells

…, MÈ Tremblay, IL King, J Qi, HM Reynolds, DF Marker… - PloS one, 2011 - journals.plos.org
Despite the ability of combination antiretroviral treatment (cART) to reduce viral burden to
nearly undetectable levels in cerebrospinal fluid and serum, HIV-1 associated neurocognitive …

[HTML][HTML] Homozygous deletion of CDKN2A by fluorescence in situ hybridization is prognostic in grade 4, but not grade 2 or 3, IDH-mutant astrocytomas

DF Marker, TM Pearce - Acta Neuropathologica Communications, 2020 - Springer
… In conclusion, CDKN2A homozygous deletion is a marker of poor prognosis in histologic
grade 4 IDHm astrocytomas, but the impact of this finding in histologic grades 2 and 3 tumors is …