The inhibitory extracellular environment that develops in response to traumatic brain injury
and spinal cord injury hinders axon growth thereby limiting restoration of function. Several …

Two recurring problems with stem/neural progenitor cell (NPC) transplantation therapies for
spinal cord injury (SCI) are poor cell survival and uncontrolled cell differentiation. The …

From the combined perspective of biologists, microscope instrumentation developers,
imaging core facility scientists, and high performance computing experts, we discuss the …

The spinal cord consists of multiple neuronal cell types that are critical to motor control and
arise from distinct progenitor domains in the developing neural tube. Excitatory V2a …

Embryonic stem (ES) cells can be differentiated into many neural cell types that hold great
potential in cell replacement therapies following spinal cord injury (SCI). Coupling stem cell …

Neural progenitor cell (NPC) transplantation is a promising therapeutic strategy for replacing
lost neurons following spinal cord injury (SCI). However, how graft cellular composition …

V2a interneurons of the ventral spinal cord and hindbrain play an important role in the
central pattern generators (CPGs) involved in locomotion, skilled reaching, and respiration. …

The spinal cord is unable to regenerate after injury largely due to growth‐inhibition by an
inflammatory response to the injury that fails to resolve, resulting in secondary damage and cell …

Direct reprogramming strategies enable rapid conversion of somatic cells to cardiomyocytes
or cardiomyocyte-like cells without going through the pluripotent state. A recently described …

The muscular dystrophy X-linked mouse (mdx) is the most commonly used preclinical model
for Duchenne muscular dystrophy. Although disease progression in the mouse does not …