User profiles for D. A. Lewis

David A Lewis

University of Pittsburgh
Verified email at upmc.edu
Cited by 72692

Cortical inhibitory neurons and schizophrenia

DA Lewis, T Hashimoto, DW Volk - Nature Reviews Neuroscience, 2005 - nature.com
Impairments in certain cognitive functions, such as working memory, are core features of
schizophrenia. Convergent findings indicate that a deficiency in signalling through the TrkB …

Schizophrenia as a disorder of neurodevelopment

DA Lewis, P Levitt - Annual review of neuroscience, 2002 - annualreviews.org
▪ Abstract A combination of genetic susceptibility and environmental perturbations appear to
be necessary for the expression of schizophrenia. In addition, the pathogenesis of the …

[PDF][PDF] Catching up on schizophrenia: natural history and neurobiology

DA Lewis, JA Lieberman - Neuron, 2000 - cell.com
… established fact that putative marker of MD axon terminals appear to be reantipsychotic
medications can alleviate the psychotic duced in the PFC of subjects with schizophrenia (Lewis, …

Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia

LA Glantz, DA Lewis - Archives of general psychiatry, 2000 - jamanetwork.com
Background The pathophysiological characteristics of schizophrenia appear to involve altered
synaptic connectivity in the dorsolateral prefrontal cortex. Given the central role that layer …

Observation of tev gamma-rays from the crab nebula using the atmospheric cherenkov imaging technique

…, PW Kowk, RC Lamb, DA Lewis… - Astrophysical …, 1989 - mural.maynoothuniversity.ie
The Whipple Observatory 10-m reflector, operating as a 37-pixel camera, has been used to
observe the Crab Nebula in TeV gamma rays. By selecting gamma-ray images based on …

Gene expression elucidates functional impact of polygenic risk for schizophrenia

…, H Toyoshiba, RE Gur, CG Hahn, DA Lewis… - Nature …, 2016 - nature.com
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral …

Detection of TeV photons from the active galaxy Markarian 421

…, AD Kerrick, RC Lamb, MA Lawrence, DA Lewis… - nature, 1992 - nature.com
PHOTONS of TeV energy have been observed from a few sources in our Galaxy, notably the
Crab Nebula 1 . We report here the detection of such photons from an extragalactic source, …

[HTML][HTML] Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia

DA Lewis, AA Curley, JR Glausier, DW Volk - Trends in neurosciences, 2012 - cell.com
Deficits in cognitive control, a core disturbance of schizophrenia, appear to emerge from
impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory …

Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia

…, JN Pierri, Z Sun, AR Sampson, DA Lewis - Journal of …, 2003 - Soc Neuroscience
Markers of inhibitory neurotransmission are altered in the prefrontal cortex (PFC) of subjects
with schizophrenia, and several lines of evidence suggest that these alterations may be …

[HTML][HTML] Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex

K Mirnics, FA Middleton, A Marquez, DA Lewis, P Levitt - Neuron, 2000 - cell.com
Microarray expression profiling of prefrontal cortex from matched pairs of schizophrenic and
control subjects and hierarchical data analysis revealed that transcripts encoding proteins …