User profiles for D. A. Lewis
David A LewisUniversity of Pittsburgh Verified email at upmc.edu Cited by 72692 |
Cortical inhibitory neurons and schizophrenia
DA Lewis, T Hashimoto, DW Volk - Nature Reviews Neuroscience, 2005 - nature.com
Impairments in certain cognitive functions, such as working memory, are core features of
schizophrenia. Convergent findings indicate that a deficiency in signalling through the TrkB …
schizophrenia. Convergent findings indicate that a deficiency in signalling through the TrkB …
Schizophrenia as a disorder of neurodevelopment
▪ Abstract A combination of genetic susceptibility and environmental perturbations appear to
be necessary for the expression of schizophrenia. In addition, the pathogenesis of the …
be necessary for the expression of schizophrenia. In addition, the pathogenesis of the …
[PDF][PDF] Catching up on schizophrenia: natural history and neurobiology
DA Lewis, JA Lieberman - Neuron, 2000 - cell.com
… established fact that putative marker of MD axon terminals appear to be reantipsychotic
medications can alleviate the psychotic duced in the PFC of subjects with schizophrenia (Lewis, …
medications can alleviate the psychotic duced in the PFC of subjects with schizophrenia (Lewis, …
Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia
LA Glantz, DA Lewis - Archives of general psychiatry, 2000 - jamanetwork.com
Background The pathophysiological characteristics of schizophrenia appear to involve altered
synaptic connectivity in the dorsolateral prefrontal cortex. Given the central role that layer …
synaptic connectivity in the dorsolateral prefrontal cortex. Given the central role that layer …
Observation of tev gamma-rays from the crab nebula using the atmospheric cherenkov imaging technique
…, PW Kowk, RC Lamb, DA Lewis… - Astrophysical …, 1989 - mural.maynoothuniversity.ie
The Whipple Observatory 10-m reflector, operating as a 37-pixel camera, has been used to
observe the Crab Nebula in TeV gamma rays. By selecting gamma-ray images based on …
observe the Crab Nebula in TeV gamma rays. By selecting gamma-ray images based on …
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral …
confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral …
Detection of TeV photons from the active galaxy Markarian 421
…, AD Kerrick, RC Lamb, MA Lawrence, DA Lewis… - nature, 1992 - nature.com
PHOTONS of TeV energy have been observed from a few sources in our Galaxy, notably the
Crab Nebula 1 . We report here the detection of such photons from an extragalactic source, …
Crab Nebula 1 . We report here the detection of such photons from an extragalactic source, …
[HTML][HTML] Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
DA Lewis, AA Curley, JR Glausier, DW Volk - Trends in neurosciences, 2012 - cell.com
Deficits in cognitive control, a core disturbance of schizophrenia, appear to emerge from
impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory …
impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory …
Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia
Markers of inhibitory neurotransmission are altered in the prefrontal cortex (PFC) of subjects
with schizophrenia, and several lines of evidence suggest that these alterations may be …
with schizophrenia, and several lines of evidence suggest that these alterations may be …
[HTML][HTML] Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex
Microarray expression profiling of prefrontal cortex from matched pairs of schizophrenic and
control subjects and hierarchical data analysis revealed that transcripts encoding proteins …
control subjects and hierarchical data analysis revealed that transcripts encoding proteins …