User profiles for Clement Hamani

Clement Hamani

Sunnybrook Research Institute
Verified email at sunnybrook.ca
Cited by 24148

A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease

…, R Keren, J Wherrett, G Naglie, C Hamani… - Annals of …, 2010 - Wiley Online Library
Objective Alzheimer disease (AD) is characterized by functional impairment in the neural
elements and circuits underlying cognitive and memory functions. We hypothesized that fornix/…

[PDF][PDF] Deep brain stimulation for treatment-resistant depression

…, V Voon, HE McNeely, D Seminowicz, C Hamani… - Neuron, 2005 - cell.com
Treatment-resistant depression is a severely disabling disorder with no proven treatment
options once multiple medications, psychotherapy, and electroconvulsive therapy have failed. …

Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression

AM Lozano, HS Mayberg, P Giacobbe, C Hamani… - Biological …, 2008 - Elsevier
BACKGROUND: A preliminary report in six patients suggested that deep brain stimulation (DBS)
of the subcallosal cingulate gyrus (SCG) may provide benefit in treatment-resistant …

Memory enhancement induced by hypothalamic/fornix deep brain stimulation

C Hamani, MP McAndrews, M Cohn… - Annals of Neurology …, 2008 - Wiley Online Library
Bilateral hypothalamic deep brain stimulation was performed to treat a patient with morbid
obesity. We observed, quite unexpectedly, that stimulation evoked detailed autobiographical …

The subthalamic nucleus in the context of movement disorders

C Hamani, JA Saint‐Cyr, J Fraser, M Kaplitt… - Brain, 2004 - academic.oup.com
The subthalamic nucleus (STN) has been regarded as an important modulator of basal ganglia
output. It receives its major afferents from the cerebral cortex, thalamus, globus pallidus …

Neuromodulation for chronic pain

H Knotkova, C Hamani, E Sivanesan, MFE Le Beuffe… - The Lancet, 2021 - thelancet.com
Neuromodulation is an expanding area of pain medicine that incorporates an array of non-invasive,
minimally invasive, and surgical electrical therapies. In this Series paper, we focus …

The subcallosal cingulate gyrus in the context of major depression

C Hamani, H Mayberg, S Stone, A Laxton, S Haber… - Biological …, 2011 - Elsevier
The subcallosal cingulate gyrus (SCG), including Brodmann area 25 and parts of 24 and 32,
is the portion of the cingulum that lies ventral to the corpus callosum. It constitutes an …

Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial

…, K Matthews, DL Peichel, RE Gross, C Hamani… - The Lancet …, 2017 - thelancet.com
Background Deep brain stimulation (DBS) of the subcallosal cingulate white matter has
shown promise as an intervention for patients with chronic, unremitting depression. To test the …

Unilateral pedunculopontine stimulation improves falls in Parkinson's disease

E Moro, C Hamani, YY Poon, T Al-Khairallah… - Brain, 2010 - academic.oup.com
Postural instability and falls are a major source of disability in patients with advanced Parkinson's
disease. These problems are currently not well addressed by either pharmacotherapy …

[HTML][HTML] First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

…, Y Meng, M Llinas, Y Huang, C Hamani… - Nature …, 2019 - nature.com
MR-guided focused ultrasound (MRgFUS) is an emerging technology that can accurately
and transiently permeabilize the blood-brain barrier (BBB) for targeted drug delivery to the …