Opiate drugs have potent analgesic and addictive properties. These drugs interact with
receptors that also mediate the response to endogenous opioid peptide ligands. However, the …

Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective
drugs known for acute relief of severe pain. A major problem in treating painful conditions is …

Background Current estimates suggest that approximately 75% of people approaching the
end-of-life may benefit from palliative care. The growing numbers of older people and …

We have examined the endocytic trafficking of epitope-tagged δ and µ opioid receptors
expressed in human embryonic kidney (HEK) 293 cells. These receptors are activated by peptide …

μ-Opioid receptors are the pharmacological targets of endogenous opioid peptides and
morphine-like alkaloid drugs. Previous studies of transfected cells and peripheral neurons …

Topography of surfaces produced in finish hard turning using cubic boron nitride (CBN) tools
is affected by a large number of factors including tool wear and the mechanics of the chip …

Buprenorphine is a mixed opioid receptor agonist-antagonist used clinically for maintenance
therapy in opiate addicts and pain management. Dose-response curves for buprenorphine-…

We present a dense grid of evolutionary tracks and isochrones of rotating massive main-sequence
stars. We provide three grids with different initial compositions tailored to compare …

Astrocytes tile the central nervous system, but their functions in neural microcircuits in vivo
and their roles in mammalian behavior remain incompletely defined. We used two-photon …

Chronic migraine is an incredibly disabling disorder. We developed a translationally
significant model of chronic migraine which can be used to test promising new antimigraine …