Objectives To examine the effects of aerobic exercise on cognition and other biomarkers
associated with Alzheimer disease pathology for older adults with mild cognitive impairment, …

Background: Reduced brain insulin signaling and low CSF-to-plasma insulin ratios have been
observed in patients with Alzheimer disease (AD). Furthermore, intracerebroventricular or …

BACKGROUND: Preclinical research findings suggest that exposure to stress and concomitant
hypothalamus-pituitary-adrenal (HPA) axis activation during early development can have …

Research suggests that disruptions in early caretaking can have long-term effects on the
hypothalamic–pituitary–adrenal (HPA) axis, which mediates the stress response. Children of …

In the present article, we report on two studies performed in young human populations which
tested the cognitive impact of glucocorticoids (GC) in situations of decreased or increased …

Background Increasing plasma glucose levels improves memory in patients with Alzheimer
disease (AD). Increasing plasma glucose levels also increases endogenous insulin levels, …

Possible differences between men and women in age-related patterns of hypothalamic–pituitary–adrenal
(HPA) axis response to challenge were examined to test the hypothesis that …

Impaired glucose regulation is a defining characteristic of type 2 diabetes mellitus (T2DM)
pathology and has been linked to increased risk of cognitive impairment and dementia. …

BACKGROUND: Several decades of research link childhood parental loss with risk for
major depression and other forms of psychopathology. A large body of preclinical work on …

Background Traffic-related air pollution is consistently associated with cardiovascular morbidity
and mortality. Recent human and animal studies suggest that exposure to air pollutants …