User profiles for C. Andrew Frank

C. Andrew Frank

The University of Iowa Carver College of Medicine and the Iowa Neuroscience Institute
Verified email at uiowa.edu
Cited by 1522

[HTML][HTML] Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis

CA Frank, MJ Kennedy, CP Goold, KW Marek… - Neuron, 2006 - cell.com
Homeostatic signaling systems are thought to interface with the mechanisms of neural plasticity
to achieve stable yet flexible neural circuitry. However, the time course, molecular design…

[PDF][PDF] A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2. 1 calcium channels

CA Frank, J Pielage, GW Davis - Neuron, 2009 - cell.com
The molecular mechanisms underlying the homeostatic modulation of presynaptic
neurotransmitter release remain largely unknown. In a screen, we isolated mutations in Drosophila …

Homeostatic plasticity at the Drosophila neuromuscular junction

CA Frank - Neuropharmacology, 2014 - Elsevier
In biology, homeostasis refers to how cells maintain appropriate levels of activity. This concept
underlies a balancing act in the nervous system. Synapses require flexibility (ie plasticity) …

[PDF][PDF] Hierarchical microtubule organization controls axon caliber and transport and determines synaptic structure and stability

…, E Moreno, CA Frank, T Hugenschmidt, C Genoud… - Developmental cell, 2015 - cell.com
C terminus might directly associate with MTs. Indeed, a His-tagged fusion protein of the first
part of the C … -terminal fusion protein, demonstrating that the C terminus binds to MTs in vitro (…

Homeostatic control of Drosophila neuromuscular junction function

CA Frank, TD James, M Müller - Synapse, 2020 - Wiley Online Library
The ability to adapt to changing internal and external conditions is a key feature of biological
systems. Homeostasis refers to a regulatory process that stabilizes dynamic systems to …

The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions

S Cordes, CA Frank, G Garriga - 2006 - journals.biologists.com
In the nematode Caenorhabditis elegans, neurons are generated from asymmetric divisions
in which a mother cell divides to produce daughters that differ in fate. Here, we demonstrate …

HLH-14 is a C. elegans Achaete-Scute protein that promotes neurogenesis through asymmetric cell division

CA Frank, PD Baum, G Garriga - 2003 - journals.biologists.com
Achaete-Scute basic helix-loop-helix (bHLH) proteins promote neurogenesis during metazoan
development. In this study, we characterize a C. elegans Achaete-Scute homolog, HLH-…

[HTML][HTML] How voltage-gated calcium channels gate forms of homeostatic synaptic plasticity

CA Frank - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Throughout life, animals face a variety of challenges such as developmental growth, the
presence of toxins, or changes in temperature. Neuronal circuits and synapses respond to …

[HTML][HTML] A single-cross, RNA interference-based genetic tool for examining the long-term maintenance of homeostatic plasticity

DJ Brusich, AM Spring, CA Frank - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Homeostatic synaptic plasticity (HSP) helps neurons and synapses maintain physiologically
appropriate levels of output. The fruit fly Drosophila melanogaster larval neuromuscular …

The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of the HSN motor neuron

PD Baum, C Guenther, CA Frank, BV Pham… - Genes & …, 1999 - genesdev.cshlp.org
The Caenorhabditis elegans HSN motor neurons permit genetic analysis of neuronal
development at single-cell resolution. Theegl-5 Hox gene, which patterns the posterior of the …