User profiles for Brian A Kidd

Brian A. Kidd

Scientific Senior Director, Predictive Sciences at Bristol-Myers Squibb
Verified email at bms.com
Cited by 8715

[HTML][HTML] Deep patient: an unsupervised representation to predict the future of patients from the electronic health records

R Miotto, L Li, BA Kidd, JT Dudley - Scientific reports, 2016 - nature.com
Secondary use of electronic health records (EHRs) promises to advance clinical research
and better inform clinical decision making. Challenges in summarizing and representing …

Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite

…, H Garren, EM Hur, R Gupta, LY Lee, BA Kidd… - Science, 2005 - science.org
Local catabolism of the amino acid tryptophan (Trp) by indoleamine 2,3-dioxygenase (IDO)
is considered an important mechanism of regulating T cell immunity. We show that IDO …

[PDF][PDF] Virus-specific CD4+ memory-phenotype T cells are abundant in unexposed adults

LF Su, BA Kidd, A Han, JJ Kotzin, MM Davis - Immunity, 2013 - cell.com
Although T cell memory is generally thought to require direct antigen exposure, we found an
abundance of memory-phenotype cells (20%–90%, averaging over 50%) of CD4 + T cells …

Antigen microarray profiling of autoantibodies in rheumatoid arthritis

W Hueber, BA Kidd, BH Tomooka, BJ Lee… - Arthritis & …, 2005 - Wiley Online Library
Objective Because rheumatoid arthritis (RA) is a heterogeneous autoimmune disease in
terms of disease manifestations, clinical outcomes, and therapeutic responses, we developed …

Cytomegalovirus infection enhances the immune response to influenza

…, CJ L. Angel, S Onengut-Gumuscu, BA Kidd… - Science translational …, 2015 - science.org
Cytomegalovirus (CMV) is a β-herpesvirus present in a latent form in most people worldwide.
In immunosuppressed individuals, CMV can reactivate and cause serious clinical …

[PDF][PDF] Clonal deletion prunes but does not eliminate self-specific αβ CD8+ T lymphocytes

W Yu, N Jiang, PJR Ebert, BA Kidd, S Müller, PJ Lund… - Immunity, 2015 - cell.com
It has long been thought that clonal deletion efficiently removes almost all self-specific T cells
from the peripheral repertoire. We found that self-peptide MHC-specific CD8 + T cells in the …

In silico methods for drug repurposing and pharmacology

RA Hodos, BA Kidd, K Shameer… - … Systems Biology and …, 2016 - Wiley Online Library
Data in the biological, chemical, and clinical domains are accumulating at ever‐increasing
rates and have the potential to accelerate and inform drug development in new ways. …

[HTML][HTML] Structural basis for mechanical force regulation of the adhesin FimH via finger trap-like β sheet twisting

I Le Trong, P Aprikian, BA Kidd, M Forero-Shelton… - Cell, 2010 - cell.com
The Escherichia coli fimbrial adhesive protein, FimH, mediates shear-dependent binding to
mannosylated surfaces via force-enhanced allosteric catch bonds, but the underlying …

Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization

EW Newell, N Sigal, N Nair, BA Kidd… - Nature …, 2013 - nature.com
It is currently not possible to predict which epitopes will be recognized by T cells in different
individuals. This is a barrier to the thorough analysis and understanding of T-cell responses …

A functional genomics predictive network model identifies regulators of inflammatory bowel disease

…, EM Neiman, SR Llewellyn, A Di Narzo, BA Kidd… - Nature …, 2017 - nature.com
A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data
sets to construct predictive models of IBD. We present a predictive model of the immune …