User profiles for Brian A Kidd
Brian A. KiddScientific Senior Director, Predictive Sciences at Bristol-Myers Squibb Verified email at bms.com Cited by 8715 |
[HTML][HTML] Deep patient: an unsupervised representation to predict the future of patients from the electronic health records
Secondary use of electronic health records (EHRs) promises to advance clinical research
and better inform clinical decision making. Challenges in summarizing and representing …
and better inform clinical decision making. Challenges in summarizing and representing …
Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite
Local catabolism of the amino acid tryptophan (Trp) by indoleamine 2,3-dioxygenase (IDO)
is considered an important mechanism of regulating T cell immunity. We show that IDO …
is considered an important mechanism of regulating T cell immunity. We show that IDO …
[PDF][PDF] Virus-specific CD4+ memory-phenotype T cells are abundant in unexposed adults
Although T cell memory is generally thought to require direct antigen exposure, we found an
abundance of memory-phenotype cells (20%–90%, averaging over 50%) of CD4 + T cells …
abundance of memory-phenotype cells (20%–90%, averaging over 50%) of CD4 + T cells …
Antigen microarray profiling of autoantibodies in rheumatoid arthritis
W Hueber, BA Kidd, BH Tomooka, BJ Lee… - Arthritis & …, 2005 - Wiley Online Library
Objective Because rheumatoid arthritis (RA) is a heterogeneous autoimmune disease in
terms of disease manifestations, clinical outcomes, and therapeutic responses, we developed …
terms of disease manifestations, clinical outcomes, and therapeutic responses, we developed …
Cytomegalovirus infection enhances the immune response to influenza
…, CJ L. Angel, S Onengut-Gumuscu, BA Kidd… - Science translational …, 2015 - science.org
Cytomegalovirus (CMV) is a β-herpesvirus present in a latent form in most people worldwide.
In immunosuppressed individuals, CMV can reactivate and cause serious clinical …
In immunosuppressed individuals, CMV can reactivate and cause serious clinical …
[PDF][PDF] Clonal deletion prunes but does not eliminate self-specific αβ CD8+ T lymphocytes
It has long been thought that clonal deletion efficiently removes almost all self-specific T cells
from the peripheral repertoire. We found that self-peptide MHC-specific CD8 + T cells in the …
from the peripheral repertoire. We found that self-peptide MHC-specific CD8 + T cells in the …
In silico methods for drug repurposing and pharmacology
Data in the biological, chemical, and clinical domains are accumulating at ever‐increasing
rates and have the potential to accelerate and inform drug development in new ways. …
rates and have the potential to accelerate and inform drug development in new ways. …
[HTML][HTML] Structural basis for mechanical force regulation of the adhesin FimH via finger trap-like β sheet twisting
I Le Trong, P Aprikian, BA Kidd, M Forero-Shelton… - Cell, 2010 - cell.com
The Escherichia coli fimbrial adhesive protein, FimH, mediates shear-dependent binding to
mannosylated surfaces via force-enhanced allosteric catch bonds, but the underlying …
mannosylated surfaces via force-enhanced allosteric catch bonds, but the underlying …
Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization
It is currently not possible to predict which epitopes will be recognized by T cells in different
individuals. This is a barrier to the thorough analysis and understanding of T-cell responses …
individuals. This is a barrier to the thorough analysis and understanding of T-cell responses …
A functional genomics predictive network model identifies regulators of inflammatory bowel disease
…, EM Neiman, SR Llewellyn, A Di Narzo, BA Kidd… - Nature …, 2017 - nature.com
A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data
sets to construct predictive models of IBD. We present a predictive model of the immune …
sets to construct predictive models of IBD. We present a predictive model of the immune …