Neurotoxic reactive astrocytes are induced by activated microglia
Reactive astrocytes are strongly induced by central nervous system (CNS) injury and disease,
but their role is poorly understood. Here we show that a subtype of reactive astrocytes, …
but their role is poorly understood. Here we show that a subtype of reactive astrocytes, …
[PDF][PDF] Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
…, RM Ransohoff, ME Greenberg, BA Barres, B Stevens - Neuron, 2012 - cell.com
Microglia are the resident CNS immune cells and active surveyors of the extracellular
environment. While past work has focused on the role of these cells during disease, recent …
environment. While past work has focused on the role of these cells during disease, recent …
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Synapse loss in Alzheimer’s disease (AD) correlates with cognitive decline. Involvement of
microglia and complement in AD has been attributed to neuroinflammation, prominent late in …
microglia and complement in AD has been attributed to neuroinflammation, prominent late in …
[HTML][HTML] The classical complement cascade mediates CNS synapse elimination
During development, the formation of mature neural circuits requires the selective elimination
of inappropriate synaptic connections. Here we show that C1q, the initiating protein in the …
of inappropriate synaptic connections. Here we show that C1q, the initiating protein in the …
Microglia emerge as central players in brain disease
MW Salter, B Stevens - Nature medicine, 2017 - nature.com
There has been an explosion of new findings recently giving us insights into the involvement
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …
Schizophrenia risk from complex variation of complement component 4
…, MJ Daly, MC Carroll, B Stevens… - Nature, 2016 - nature.com
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms.
Schizophrenia’s strongest genetic association at a population level involves variation in the major …
Schizophrenia’s strongest genetic association at a population level involves variation in the major …
[PDF][PDF] Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes
…, RJM Franklin, X Piao, SA McCarroll, B Stevens - Immunity, 2019 - cell.com
Microglia, the resident immune cells of the brain, rapidly change states in response to their
environment, but we lack molecular and functional signatures of different microglial …
environment, but we lack molecular and functional signatures of different microglial …
Microglia states and nomenclature: A field at its crossroads
Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." …
by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." …
Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain
A key aspect of nearly all single-cell sequencing experiments is dissociation of intact tissues
into single-cell suspensions. While many protocols have been optimized for optimal cell …
into single-cell suspensions. While many protocols have been optimized for optimal cell …
The complement system: an unexpected role in synaptic pruning during development and disease
…, BA Barres, B Stevens - Annual review of …, 2012 - annualreviews.org
An unexpected role for the classical complement cascade in the elimination of central
nervous system (CNS) synapses has recently been discovered. Complement proteins are …
nervous system (CNS) synapses has recently been discovered. Complement proteins are …