Neurotoxic reactive astrocytes are induced by activated microglia

…, DH Rowitch, VL Dawson, TM Dawson, B Stevens… - Nature, 2017 - nature.com
Reactive astrocytes are strongly induced by central nervous system (CNS) injury and disease,
but their role is poorly understood. Here we show that a subtype of reactive astrocytes, …

[PDF][PDF] Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner

…, RM Ransohoff, ME Greenberg, BA Barres, B Stevens - Neuron, 2012 - cell.com
Microglia are the resident CNS immune cells and active surveyors of the extracellular
environment. While past work has focused on the role of these cells during disease, recent …

Complement and microglia mediate early synapse loss in Alzheimer mouse models

…, BA Barres, CA Lemere, DJ Selkoe, B Stevens - Science, 2016 - science.org
Synapse loss in Alzheimer’s disease (AD) correlates with cognitive decline. Involvement of
microglia and complement in AD has been attributed to neuroinflammation, prominent late in …

[HTML][HTML] The classical complement cascade mediates CNS synapse elimination

B Stevens, NJ Allen, LE Vazquez, GR Howell… - Cell, 2007 - cell.com
During development, the formation of mature neural circuits requires the selective elimination
of inappropriate synaptic connections. Here we show that C1q, the initiating protein in the …

Microglia emerge as central players in brain disease

MW Salter, B Stevens - Nature medicine, 2017 - nature.com
There has been an explosion of new findings recently giving us insights into the involvement
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …

Schizophrenia risk from complex variation of complement component 4

…, MJ Daly, MC Carroll, B Stevens… - Nature, 2016 - nature.com
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms.
Schizophrenia’s strongest genetic association at a population level involves variation in the major …

[PDF][PDF] Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes

…, RJM Franklin, X Piao, SA McCarroll, B Stevens - Immunity, 2019 - cell.com
Microglia, the resident immune cells of the brain, rapidly change states in response to their
environment, but we lack molecular and functional signatures of different microglial …

Microglia states and nomenclature: A field at its crossroads

RC Paolicelli, A Sierra, B Stevens, ME Tremblay… - Neuron, 2022 - cell.com
Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." …

Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain

…, DA Hafler, RJM Franklin, EZ Macosko, B Stevens - Nature …, 2022 - nature.com
A key aspect of nearly all single-cell sequencing experiments is dissociation of intact tissues
into single-cell suspensions. While many protocols have been optimized for optimal cell …

The complement system: an unexpected role in synaptic pruning during development and disease

…, BA Barres, B Stevens - Annual review of …, 2012 - annualreviews.org
An unexpected role for the classical complement cascade in the elimination of central
nervous system (CNS) synapses has recently been discovered. Complement proteins are …